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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,886 questions in 74 reviews · Skin
current versionsNo studies 542 · 28.7%Ungraded 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg Change in health‐related quality of life (HRQOL) ‐ not measured · patients with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg Change in BMI ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Flutamide 250 mg once to b.i.d. vs spironolactone 100 mg Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Spironolactone 100 mg vs placebo Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 9 [0.55, 147.95] | 1 study · 20 participants | Low |
Spironolactone 100 mg vs placebo Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Spironolactone 100 mg vs placebo Proportion of participants who reported an adverse event · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 5 [0.7, 35.5] | 1 study · 20 participants | Low |
Spironolactone 100 mg vs placebo Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 1 study · 20 participants | Low |
Spironolactone 100 mg vs placebo Change in serum androgen levels · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 1 study · 20 participants | Low |
Spironolactone 100 mg vs placebo Change in BMI ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Spironolactone 100 mg vs placebo Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg to 7.5 mg vs placebo Participant‐reported improvement of hirsutism 3‐point (Lakryc 2003) and 4‐point (Moghetti 2000) Likert scale · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 54 participants | Very low |
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg Proportion of participants who reported an adverse event · patients with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 0.41 [0.08, 2.05] | 1 study · 100 participants | Moderate |
Finasteride 5 mg to 7.5 mg vs placebo Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg to 7.5 mg vs placebo Proportion of participants who reported an adverse event · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 1.13 [0.48, 2.67] | 3 studies · 67 participants | Very low |
Finasteride 5 mg to 7.5 mg vs placebo Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 3 studies · 62 participants | Very low |
Finasteride 5 mg to 7.5 mg vs placebo Change in serum androgen levels · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 3 studies · 52 participants | Low |
Finasteride 5 mg to 7.5 mg vs placebo Change in BMI kg/m2 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 1 study · 24 participants | Very low |
Finasteride 5 mg to 7.5 mg vs placebo Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Metformin 500 mg to 2550 mg per day vs placebo Participant‐reported improvement of hirsutism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Metformin 500 mg to 2550 mg per day vs placebo Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Metformin 500 mg to 2550 mg per day vs placebo Proportion of participants who reported an adverse event · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 63 participants | Very low |
Metformin 500 mg to 2550 mg per day vs placebo Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 7 studies · 264 participants | Low |
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · patients with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 3 studies · 164 participants | Low |
Metformin 500 mg to 2550 mg per day vs placebo Change in serum androgen levels · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 8 studies · 309 participants | Moderate |
Metformin 500 mg to 2550 mg per day vs placebo Change in BMI kg/m2 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 5 studies · 252 participants | Moderate |
Metformin 500 mg to 2550 mg per day vs placebo Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg vs spironolactone 100 mg Participant‐reported improvement of hirsutism 4‐point (Moghetti 2000) and 6‐point (Wong 1995) Likert scale · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 34 participants | Low |
Finasteride 5 mg vs spironolactone 100 mg Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg vs spironolactone 100 mg Proportion of participants who reported an adverse event · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 0.2 [0.03, 1.41] | 1 study · 20 participants | Moderate |
Finasteride 5 mg vs spironolactone 100 mg Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 34 participants | Low |
Finasteride 5 mg vs spironolactone 100 mg Change in serum androgen levels · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 34 participants | Low |
Finasteride 5 mg vs spironolactone 100 mg Change in BMI ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg vs spironolactone 100 mg Improvement of other clinical signs of hyperandrogenism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg Change in serum androgen levels · patients with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 4 studies · 184 participants | High |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Participant‐reported improvement of hirsutism ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Proportion of participants who reported an adverse event · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 2 [0.41, 9.71] | 1 study · 40 participants | Very low |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Clinician's assessment of improvement of hirsutism3 Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 3 studies · 95 participants | Very low |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Change in serum androgen levels · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 3 studies · 95 participants | Moderate |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Change in BMI3 kg/m² · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 3 studies · 95 participants | Very low |
Flutamide 250 mg once to twice daily vs metformin 1275 mg to 1700 mg per day Improvement of other clinical signs of hyperandrogenism · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 55 participants | Moderate |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Participant‐reported improvement of hirsutism 4‐point Likert scale · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 0.63 [0.31, 1.25] | 1 study · 20 participants | Low |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Change in health‐related quality of life (HRQOL) ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Proportion of participants who reported an adverse event · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | RR 3.87 [0.57, 26.24] | 3 studies · 115 participants | Very low |
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg Change in BMI kg/m² · patients with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 2 studies · 136 participants | Moderate |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Clinician's assessment of improvement of hirsutism Ferriman‐Gallwey score Scale from: 0 to 36 · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 4 studies · 226 participants | Very low |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Change in serum androgen levels · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 4 studies · 226 participants | Moderate |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Change in BMI ‐ not measured · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | NR | No studies |
Finasteride 5 mg vs flutamide 250 mg once to b.i.d. Improvement of other clinical signs of hyperandrogenism · women with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 1 study · 110 participants | High |
Ethinyl estradiol 35 μg + cyproterone acetate 2 mg vs ethinyl estradiol 30 μg + desogestrel 0.15 mg Improvement of other clinical signs of hyperandrogenism Acne score ‐ grade 1 to 4 (higher is worse) · patients with hirsutism Interventions for hirsutism (excluding laser and photoepilation therapy alone) (2015) · Cochrane | no estimate extracted | 1 study · 100 participants | Moderate |