Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

676 questions · 705 findings · 98 reviews · Headline outcomes only

No studies found 183 · 26%GRADE not reported 47 · 6.7%Very low 209 · 29.6%Low 153 · 21.7%Moderate 85 · 12.1%High 28 · 4%

Intervention not reported

Mortality or tracheostomy at 12 months (pooled hazard ratio)(riluzole 100 mg) · patients with ALS/MND

The intervention showed no clear difference in mortality or tracheostomy at 12 months (pooled hazard… (high certainty).

1 finding from 1 review

Intervention not reported

Per cent mortality at 12 months (riluzole 100 mg) · patients with ALS/MND

The intervention leads to lower per cent mortality at 12 months (riluzole 100 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Adverse event: 3‐fold increase in alanine transferase · patients with ALS/MND

The intervention leads to higher adverse event: 3‐fold increase in alanine transferase (high certainty).

1 finding from 1 review