Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

954 questions · 963 findings · 130 reviews · Headline outcomes only

No studies found 181 · 18.8%GRADE not reported 71 · 7.4%Very low 163 · 16.9%Low 311 · 32.3%Moderate 163 · 16.9%High 74 · 7.7%

Magnesium sulphate vs placebo (outcomes

Cerebral palsy · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate leads to lower cerebral palsy (up to 2 years' corrected age)** compared with placebo (outcomes (high certainty).

2 findings from 1 review

Magnesium sulphate vs placebo (outcomes

Major disability by 18 to 24 months corrected age (aligned definition) · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in major neurodevelopmental disability (up to 2 years' corrected age)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Intraventricular haemorrhage, Papile grade 3/4 · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate probably leads to lower severe intraventricular haemorrhage (grade 3 or 4) (newborn/infant)** compared with placebo (outcomes (moderate certainty).

1 finding from 1 review

Magnesium sulphate vs placebo (outcomes

Bronchopulmonary dysplasia/chronic lung disease · women at risk of preterm birth (< 34 weeks' gestation)

Magnesium sulphate showed no clear difference in chronic lung disease/bronchopulmonary dysplasia (newborn/infant)** compared with placebo (outcomes (low certainty).

1 finding from 1 review

Intervention not reported

Caesarean section (all indications) Â · women with an abnormal CTG in labour

It is very uncertain whether the intervention changes caesarean section (all indications) Â (very low certainty).

1 finding from 1 review

Intervention not reported

Assisted vaginal birth (all indications) Â · women with an abnormal CTG in labour

It is very uncertain whether the intervention changes assisted vaginal birth (all indications) Â (very low certainty).

1 finding from 1 review

Intervention not reported

Spontaneous vaginal birth  · women with an abnormal CTG in labour

It is very uncertain whether the intervention changes spontaneous vaginal birth  (very low certainty).

1 finding from 1 review

Intervention not reported

Caesarean section (all indications) · women with an abnormal cardiotocograph (CTG) in labour

It is very uncertain whether the intervention changes caesarean section (all indications) (very low certainty).

1 finding from 1 review

Intervention not reported

Assisted vaginal birth (all indications) Â · women with an abnormal cardiotocograph (CTG) in labour

It is very uncertain whether the intervention changes assisted vaginal birth (all indications) Â (very low certainty).

1 finding from 1 review

Intervention not reported

Spontaneous vaginal birth  · women with an abnormal cardiotocograph (CTG) in labour

It is very uncertain whether the intervention changes spontaneous vaginal birth  (very low certainty).

1 finding from 1 review