Findings

What do systematic reviews say?

628 questions · 651 findings · 39 reviews · Skin

No studies found 167 · 25.7%GRADE not reported 47 · 7.2%Very low 80 · 12.3%Low 139 · 21.4%Moderate 174 · 26.7%High 44 · 6.8%

Reduction in severity of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
No studies reported this outcome.
0 studies
No studies found

Pain reduction (VAS) · People with erosive oral lichen planus

1% pimecrolimus cream showed no clear difference in pain reduction (VAS) compared with placebo (vehicle cream); GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -3.30 [-20.22, 13.62]
2 studies · 32 participants
GRADE not reported

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Eisen 1990: no adverse side-effects; transient burning sensation of mucosal surfaces during swishing of medication reported in all participants.
1 study · 8 participants
GRADE not reported

Investigator‐ or physician‐rated global assessment of disease severity · People with erosive oral lichen planus

Ciclosporin rinse led to lower physician Global Assessment (severity of disease) compared with placebo (vehicle); GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
MD -1.40 [-1.86, -0.94]
1 study · 8 participants
GRADE not reported

Partial response (>33% improvement) · People with erosive oral lichen planus

Fluocinonide in adhesive base showed no clear difference in partial response (>33% improvement) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 3.00 [0.62, 14.62]
1 study · 27 participants
GRADE not reported

Participant‐reported pain relief of 50% or greater · People with erosive oral lichen planus

Aloe vera gel led to higher pain (>=50% improvement in symptoms) compared with placebo; GRADE not reported.

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
RR 6.16 [2.35, 16.13]
1 study · 45 participants
GRADE not reported

Pain reduction (participant-reported symptoms) · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
We were unable to extract data on participant-reported symptoms for Eisen 1990 because there was no breakdown of data for the ELP subgroup.
1 study · 8 participants
GRADE not reported

Side effects · People with erosive oral lichen planus

1 finding from 1 review

Interventions for erosive lichen planus affecting mucosal sites 2012 · Cochrane All outcomes
Table 3 (Side-effects). Voute 1993: no side-effects during the study and follow-up period.
1 study · 27 participants
GRADE not reported