Findings

What do systematic reviews say?

4,587 questions · 5,761 findings · 495 reviews

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No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Oral iron vs placebo (Comparison 3)

All gastrointestinal symptoms Reported by the patients · women with postpartum iron deficiency anaemia

It is very uncertain whether oral iron changes all gastrointestinal symptoms Reported by the patients compared with placebo (Comparison 3) (very low certainty).

1 finding from 1 review

Treatment for women with postpartum iron deficiency anaemia 2015 · Cochrane Headline outcomes only
RR 1 [0.36, 2.79]
1 study · 68 participants
Very low

Oral iron vs placebo (Comparison 3)

Constipation ‐ not reported · women with postpartum iron deficiency anaemia

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for women with postpartum iron deficiency anaemia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral DHEA vs control subgrouped by differing routes of administration

Side effects: acne ‐ skin application · Women in the peri‐ or postmenopausal phase

It is very uncertain whether oral DHEA changes side effects: acne ‐ skin application compared with control subgrouped by differing routes of administration (very low certainty).

1 finding from 1 review

Dehydroepiandrosterone for women in the peri‐ or postmenopausal phase 2015 · Cochrane Headline outcomes only
OR 2.74 [0.1, 74.87]
1 study · 22 participants
Very low

Oral iron vs inactive control

All‐cause mortality · patients with anaemia

It is very uncertain whether oral iron changes mortality compared with inactive control (very low certainty).

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
RR 1.05 [0.68, 1.61]
4 studies · 659 participants
Very low

Oral iron vs inactive control

Blood transfusion · patients with anaemia

It is very uncertain whether oral iron changes proportion requiring blood transfusion compared with inactive control (very low certainty).

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
RR 0.74 [0.55, 0.99]
3 studies · 546 participants
Very low

Oral iron vs inactive control

Length of hospital stay · patients with anaemia

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 300 participants
Very low

Oral iron vs inactive control

Haemoglobin (g/dL) · patients with anaemia

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 402 participants
Very low

Oral iron vs inactive control

Quality of life · patients with anaemia

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 276 participants
Very low

Oral iron vs inactive control

Serious adverse events · patients with anaemia

It is very uncertain whether oral iron changes serious adverse events compared with inactive control (very low certainty).

1 finding from 1 review

Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
RR 0.96 [0.76, 1.22]
5 studies · 731 participants
Very low

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Participant‐reported pain relief of 50% or greater · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 6… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
6 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
RR 1.47 [1.28, 1.69]
5 studies · 646 participants
High

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Proportion of patients with >50% maximum pain relief (TOTPAR) over 2 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher proportion of patients with >50% maximum pain relief (TOTPAR) over 2… compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
2 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
RR 1.30 [1.09, 1.55]
5 studies · 645 participants
High

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Patients not using rescue medication at 6 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) leads to higher patients not using rescue medication at 6 hours compared with paracetamol (acetaminophen) (single postoperative oral dose; 600 mg… (high certainty).

1 finding from 1 review

Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes
6 hours postdosing · Ibuprofen 400 mg vs paracetamol 1000 mg
RR 1.50 [1.25, 1.79]
4 studies · 542 participants
High

IV or oral iron alone vs no treatment

Red blood cell transfusions (Subnet based on 69 studies including 18,684 participants) · patients at any age with solid cancer or haematological malignancy

IV or oral iron alone showed no clear difference in red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (low certainty).

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
RR 0.74 [0.43, 1.28]
Studies not reported
Low

IV or oral iron alone vs no treatment

Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy

IV or oral iron alone showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
RR 1.5 [0.63, 3.56]
Studies not reported
Low

IV or oral iron alone vs no treatment

Thromboembolic events · patients at any age with solid cancer or haematological malignancy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IV or oral iron alone vs no treatment

Thrombocytopenia or haemorrhage5 (Subnet based on 13 studies including 2744 participants) · patients at any age with solid cancer or haematological malignancy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IV or oral iron alone vs no treatment

Hypertension5 (Subnet based on 24 studies including 8383 participants) · patients at any age with solid cancer or haematological malignancy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IV or oral iron alone vs no treatment

On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy

IV or oral iron alone showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
RR 2.95 [0.71, 12.34]
Studies not reported
Low

IV or oral iron alone vs no treatment

Haemoglobin response (Subnet based on 31 studies including 6985 participants) · patients at any age with solid cancer or haematological malignancy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings for resveratrol plus oral anti‐diabetic drugs vs placebo plus oral anti‐diabetic drugs

Diabetes complications

The review found no eligible studies for this question.

1 finding from 1 review

Resveratrol for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found