Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

634 questions · 662 findings · 83 reviews

No studies found 177 · 26.7%GRADE not reported 97 · 14.7%Very low 182 · 27.5%Low 114 · 17.2%Moderate 66 · 10%High 26 · 3.9%

Intervention not reported

Mortality or tracheostomy at 12 months (pooled hazard ratio)(riluzole 100 mg) · patients with ALS/MND

The intervention showed no clear difference in mortality or tracheostomy at 12 months (pooled hazard… (high certainty).

1 finding from 1 review

Intervention not reported

Per cent mortality at 12 months (riluzole 100 mg) · patients with ALS/MND

The intervention leads to lower per cent mortality at 12 months (riluzole 100 mg) (high certainty).

1 finding from 1 review

Intervention not reported

Adverse event: 3‐fold increase in alanine transferase · patients with ALS/MND

The intervention leads to higher adverse event: 3‐fold increase in alanine transferase (high certainty).

1 finding from 1 review