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Evidence found and GRADE certainty

966 questions · 1,015 findings · 90 reviews · Headline outcomes only

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No studies found 256 · 25.2%GRADE not reported 62 · 6.1%Very low 271 · 26.7%Low 269 · 26.5%Moderate 111 · 10.9%High 46 · 4.5%

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones Diagnostic criteria: 2 trials applied the WHO 1999 criteria (FPG ≥ 7.0 mmol/L and/or a 2‐hour glucose ≥ 11.1 mmol/L after a 75 g OGTT) (Jin 2009; Zeng 2013). No medical association recommended the cut‐off points applied in Maji ... · people at increased risk for developing type 2 diabetes

Summary of findings table for metformin showed no clear difference in thiazolidinediones Diagnostic criteria: 2 trials applied the WHO… compared with diet and exercise or another antidiabetic drug (low certainty).

1 finding from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Acarbose · people at increased risk for developing type 2 diabetes
3 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Thiazolidinediones · people at increased risk for developing type 2 diabetes
2 findings from 1 review

Metformin vs diet and exercise or another antidiabetic drug

Acarbose Diagnostic criteria: 1 trial applied the WHO 1985 criteria (FPG < 7.8 mmol/L and 2‐hour glucose ≥ 7.8 mmol/L and < 11.1 mmol/L) (Fang 2004). 1 trial applied the WHO 1999 criteria (FPG ≥ 7.0 mmol/L and/or a 2‐hpur glucose ≥ 11.1 mmol/L aft... · people at increased risk for developing type 2 diabetes

Summary of findings table for metformin showed no clear difference in acarbose Diagnostic criteria: 1 trial applied the WHO 1985 criteria… compared with diet and exercise or another antidiabetic drug (low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Recovery during intervention defined as achieving WHZ ≥ −2 and absence of oedema in 1 study; reaching a WHZ score > −2 and without oedema in 1 study; WHZ > −2 in 1 study; having a WHZ score ≥ 0 in 1 study; reaching 100% weight for height in 1 stud... · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… probably leads to higher recovery during intervention defined as achieving WHZ ≥ −2 and… compared with an alternative dietary approach (moderate certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes relapse during intervention defined as admission to inpatient… compared with an alternative dietary approach (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Mortality during intervention · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial

It is very uncertain whether standard ready‐to‐use therapeutic food (RUTF) provided at a dose… changes mortality during intervention compared with an alternative dietary approach (very low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs an alternative dietary approach

Rate of weight gain (g/kg/day) · children aged 6 months‐5 years with SAM (and mixed HIV comorbidity), some of whom had been stabilised as inpatients pre‐trial
1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Recovery during intervention defined as WHZ > 0 in 1 study; 100% weight for height in 1 study · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… may leads to higher recovery during intervention defined as WHZ > 0 in 1 study; 100%… compared with as a supplement to the usual diet (low certainty).

1 finding from 1 review

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose that meets total daily nutritional requirements vs as a supplement to the usual diet

Relapse during intervention defined as admission to inpatient therapeutic care or recurrence of oedema or systematic infections during the study period, and dropouts during intervention period · children aged 6 months‐5 years with SAM (1 study included HIV‐uninfected children; 1 study included HIV‐infected children), all of whom…

Standard ready‐to‐use therapeutic food (RUTF) provided at a dose… may leads to lower relapse during intervention defined as admission to inpatient… compared with as a supplement to the usual diet (low certainty).

1 finding from 1 review