Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Intervention not reported

Dupilumab (3 RCTs; 1082 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in dupilumab (3 RCTs; 1082 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Fezakinumab (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes fezakinumab (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

QGE031 (1 RCT; 10 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QGE031 (1 RCT; 10 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (2 RCTs; 49 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (2 RCTs; 49 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Total studies: 13 RCTsTotal participants: 1658 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

Corticosteroid (1 RCT; 21 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes corticosteroid (1 RCT; 21 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Dupilumab (4 RCTs; 990 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes dupilumab (4 RCTs; 990 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Cyclosporin A (3 RCTs; 74 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes cyclosporin A (3 RCTs; 74 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Timapiprant (1 RCT; 70 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in timapiprant (1 RCT; 70 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Total studies: 6 RCTsTotal participants: 2680 · patients with moderate to severe eczema
1 finding from 1 review

Intervention not reported

CIM331 (1 RCT; 27 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in CIM331 (1 RCT; 27 participants) (low certainty).

1 finding from 1 review

Intervention not reported

GBR830 (1 RCT; 46 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in GBR830 (1 RCT; 46 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Azathiopine (AZA) (1 RCT; 41 participants) · patients with moderate to severe eczema

The intervention showed no clear difference in azathiopine (AZA) (1 RCT; 41 participants) (low certainty).

1 finding from 1 review

Intervention not reported

QAW039 (1 RCT; 76 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes QAW039 (1 RCT; 76 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

CsAI (1 RCT; 40 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes csAI (1 RCT; 40 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Placebo · patients with moderate to severe eczema

The review found no eligible studies for this question.

1 finding from 1 review