Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,841 questions · 1,893 findings · 109 reviews · Headline outcomes only

No studies found 546 · 28.8%GRADE not reported 117 · 6.2%Very low 613 · 32.4%Low 473 · 25%Moderate 118 · 6.2%High 26 · 1.4%

Opioids vs oral sweet solution or non‐pharmacological intervention

Pain, assessed using the CRIES pain scale, ranging from 0 to 10, during the procedure— opioids versus facilitated tucking · procedural pain in neonates
2 findings from 1 review

Antidepressants vs any other pharmacological intervention

Depression remission · women of any age, with PND up to 12 months

It is very uncertain whether antidepressants changes depression remission (acute phase, 5 ≤ 12 weeks) compared with any other pharmacological intervention (very low certainty).

2 findings from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Adverse events · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes adverse events compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review