Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

958 questions · 991 findings · 123 reviews · Headline outcomes only

No studies found 177 · 17.9%GRADE not reported 25 · 2.5%Very low 230 · 23.2%Low 321 · 32.4%Moderate 185 · 18.7%High 53 · 5.3%

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Cure · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

The review found no eligible studies for this question.

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Adverse events · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

Partial oral treatment showed no clear difference in adverse events compared with conventional intravenous treatment of endocarditis on the left side… (low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Congestive heart failure · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes congestive heart failure compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Need for cardiac surgical interventions · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes need for cardiac surgicalinterventions compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Septic embolism · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes septic embolism compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Uncontrolled infection · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

The review found no eligible studies for this question.

1 finding from 1 review

Paracervical vs intravenous diazepam/pethidine analgesia

Providers' satisfaction with the procedure · women with persistent or prolonged retention of placenta

It is very uncertain whether paracervical block changes providers' satisfaction with the procedure compared with intravenous diazepam/pethidine analgesia (very low certainty).

1 finding from 1 review

Paracervical vs intravenous diazepam/pethidine analgesia

Women's satisfaction with the procedure · women with persistent or prolonged retention of placenta

It is very uncertain whether paracervical block changes women's satisfaction with the procedure compared with intravenous diazepam/pethidine analgesia (very low certainty).

1 finding from 1 review

Effects of clinically‐indicated replacement vs routine change of peripheral intravenous catheters

Catheter‐related blood stream infection · any patient requiring a PIVC expected to remain in‐situ for at least 3 days

Effects of clinically‐indicated replacement showed no clear difference in catheter‐related blood stream infection (during hospitalisation) compared with routine change of peripheral intravenous catheters (low certainty).

1 finding from 1 review

Effects of clinically‐indicated replacement vs routine change of peripheral intravenous catheters

Thrombophlebitis (during hospitalisation) · any patient requiring a PIVC expected to remain in‐situ for at least 3 days

Effects of clinically‐indicated replacement showed no clear difference in thrombophlebitis (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).

1 finding from 1 review

Effects of clinically‐indicated replacement vs routine change of peripheral intravenous catheters

Thrombophlebitis (per device days) (during hospitalisation) · any patient requiring a PIVC expected to remain in‐situ for at least 3 days

Effects of clinically‐indicated replacement showed no clear difference in thrombophlebitis (per device days) (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).

1 finding from 1 review

Effects of clinically‐indicated replacement vs routine change of peripheral intravenous catheters

All‐cause blood stream infection (during hospitalisation) · any patient requiring a PIVC expected to remain in‐situ for at least 3 days

Effects of clinically‐indicated replacement showed no clear difference in all‐cause blood stream infection (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).

1 finding from 1 review