Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

970 questions · 979 findings · 135 reviews

No studies found 182 · 18.6%GRADE not reported 84 · 8.6%Very low 165 · 16.9%Low 311 · 31.8%Moderate 163 · 16.6%High 74 · 7.6%

Intervention not reported

Fatal injuries — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐fatal injuries — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐injury accidents — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Absenteeism — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events associated with RAT — not measured · Workers in positions with safety‐sensitive functions, other than commercial drivers

The review found no eligible studies for this question.

1 finding from 1 review

Additional support vs usual care

Death of a baby (stillbirth or neonatal death) report of perinatal death · women at increased risk of low birthweight babies (maternal outcomes)

Additional support showed no clear difference in stillbirth/neonatal death compared with usual care during pregnancy (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Complete remission · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in treatment response at 52 weeks: complete remission (primary outcome… compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Partial remission ( · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in treatment response at 52 weeks: partial remission (primary outcome 3) compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Sustainable remission between 52 and 78 weeks: complete or partial remission (primary outcome 1, 2, 3) · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in sustainable remission between 52 and 78 weeks: complete or partial… compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

CKD or death: 50% decline in GFR by 78 weeks · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in CKD or death: 50% decline in GFR by 78 weeks compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse effects (weeks 0 to 26): serious infection requiring hospitalisation · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse events: hypertension · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): hypertension compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review