Findings

What do systematic reviews say?

2,890 questions · 3,917 findings · 272 reviews · Oral Health

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No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Fluoride toothpaste containing 10% xylitol vs Fluoride toothpaste alone

Caries increment (DFS), prevented fraction at 2.5 to 3 years · Children with permanent teeth (schoolchildren)

1 finding from 1 review

Xylitol‐containing products for preventing dental caries in children and adults 2015 · Cochrane All outcomes
2.5 to 3 years
PF 0.13 [0.08, 0.18]
2 studies · 4216 participants
Low

Chlorhexidine gel (0.12%) vs no treatment

Presence of new caries in the primary teeth · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

It is very uncertain whether chlorhexidine gel (0.12%) changes presence of new caries in the primary teeth compared with no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine treatment for the prevention of dental caries in children and adolescents 2015 · Cochrane All outcomes
24 months · primary dentition
RR 1.00 [0.36, 2.77]
2 studies · 487 participants
Very low

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Caries increment on tooth surfaces (dmfs/DMFS) (prevented fraction) · Children aged 4 to 12 years attending primary school

1 finding from 1 review

Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
15 months
PF 0.65 [0.12, 1.18]
1 study · 60 participants
Low

Fluoride varnish vs placebo or no treatment

Caries increment in primary/deciduous teeth: decayed, (extraction indicated/missing) and filled teeth d(e/m)ft (prevented fraction) · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year · Primary/deciduous dentition
PF 0.65 [0.48, 0.82]
2 studies · 322 participants
GRADE not reported

Fluoride varnish vs placebo or no treatment

Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year
PF 0.44 [0.11, 0.76]
5 studies
GRADE not reported

Fluoride varnish vs placebo or no treatment

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year
PF 0.43 [0.30, 0.57]
13 studies · 6478 participants
Moderate

Fluoride varnish vs placebo or no treatment

Caries increment on primary (deciduous) tooth surfaces (d(e/m)fs), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Fluoride varnishes for preventing dental caries in children and adolescents 2013 · Cochrane All outcomes
At least 1 year · Primary/deciduous dentition
PF 0.37 [0.24, 0.51]
10 studies · 3804 participants
Moderate

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Presence/absence of HSV oral lesions · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)

Prophylactic valaciclovir (lower dose) showed no clear difference in presence/absence of HSV oral lesions compared with prophylactic valaciclovir (higher dose); GRADE not reported.

1 finding from 1 review

Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
RR 0.23 [0.05, 1.03]
2 studies · 181 participants
GRADE not reported