Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

777 questions · 792 findings · 40 reviews · Kidney and Transplant

No studies found 232 · 29.3%GRADE not reported 3 · 0.4%Very low 218 · 27.5%Low 253 · 31.9%Moderate 76 · 9.6%High 10 · 1.3%

Tacrolimus vs mycophenolate mofetil to maintain remission

Number with steroid resistance by one year · idiopathic steroid‐resistant nephrotic syndrome in children

Tacrolimus showed no clear difference in number with steroid resistance by one year compared with mycophenolate mofetil to maintain remission (low certainty).

1 finding from 1 review

Oral cyclophosphamide vs prednisone or placebo

Adverse events: hypertension with seizures · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether oral cyclophosphamide changes adverse events: hypertension with seizures compared with prednisone or placebo (very low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Complete remission (no further aphthous episodes to 6 months) · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: complete remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Treatment response at 6 months: partial remission · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in treatment response at 6 months: partial remission compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review