Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

643 questions · 693 findings · 156 reviews

No studies found 177 · 25.5%GRADE not reported 100 · 14.4%Very low 144 · 20.8%Low 139 · 20.1%Moderate 106 · 15.3%High 27 · 3.9%

Ultrasound‐accelerated thrombolysis vs thrombolysis alone

Clinical success ‐ increase in ABI by at least 0.2 · adults with ALI

It is very uncertain whether ultrasound‐accelerated thrombolysis changes clinical success ‐ increase in ABI by at least 0.2 compared with thrombolysis alone (very low certainty).

1 finding from 1 review

COE with blood/salivary (biomarker) analysis vs Conventional oral examination (COE) alone

Outcome not reported · Apparently healthy adults not reporting symptoms of OPMD or OSCC, attending an organised screening or surveillance programme, or screened…

The review found no eligible studies for this question.

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Cancer‐related mortality at maximal · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in cancer‐related mortality3 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

VTE‐related morbidity5 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in VTE‐related morbidity5 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Stage at diagnosis (early-stage detection) · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in stage of cancer ‐ early compared with standard testing alone (low certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Stage of cancer ‐ advanced · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in stage of cancer ‐ advanced compared with standard testing alone (low certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

Frequency of an underlying cancer diagnosis8 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in frequency of an underlying cancer diagnosis8 compared with standard testing alone (moderate certainty).

1 finding from 1 review

Standard testing plus PET/CT scanning vs standard testing alone

All‐cause mortality1 · people with unprovoked VTE

Standard testing plus PET/CT scanning showed no clear difference in all‐cause mortality1 compared with standard testing alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Endometrial Polyps · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to lower endometrial polyps compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Endometrial Hyperplasia · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to lower endometrial hyperplasia compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Fibroids · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in fibroids compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Abnormal Vaginal Bleeding or Spotting · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to higher abnormal vaginal bleeding or spotting compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review