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Evidence found and GRADE certainty

781 questions · 1,089 findings · 92 reviews · Dental caries

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No studies found 77 · 7.1%GRADE not reported 781 · 71.7%Very low 86 · 7.9%Low 97 · 8.9%Moderate 38 · 3.5%High 10 · 0.9%

1450 to 1500 ppm F toothpaste vs 250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).

1 finding from 1 review

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Finland

The single Finnish study showed lower DMFT/S with OHPP (OR 0.48, 95% CI 0.41 to 0.56; ungraded, single study).

1 finding from 1 review

1000 to 1250 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1000 to 1250 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste showed no clear difference in proportion developing new caries compared with 1000 to 1250 ppm F toothpaste (low certainty).

1 finding from 1 review

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published before 2015)

In studies published before 2015, OHPPs were associated with lower DMFT (OR 0.01, 95% CI 0.00 to 0.13; ungraded).

1 finding from 1 review

1000 or 1100 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Adults with mature permanent dentition (aged 18 to 93 years at study start)

1000 or 1100 ppm F toothpaste probably leads to lower caries increment, surface index DMFS compared with non-fluoride (0 ppm F) placebo toothpaste (moderate certainty).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste may leads to lower proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review

1450 to 1500 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1450 to 1500 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 1000 to 1250 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1000 to 1250 ppm F toothpaste (low certainty).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

1450 ppm F toothpaste vs 440 ppm F toothpaste

Caries increment, tooth index D(M)FT · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)

1450 ppm F toothpaste probably leads to lower caries increment, tooth index d(m)ft compared with 440 ppm F toothpaste (moderate certainty).

1 finding from 1 review

CPP-ACP vs Placebo paste without CPP-ACP (fluoride toothpaste control)

Quantitative light-induced fluorescence (QLF), fluorescence loss · Patients (mainly children) with white spot lesions (WSL)

CPP-ACP toothpaste did not differ significantly from placebo paste (fluoride control) for white spot lesion remineralization on QLF (MD 0.08, 95% CI -0.91 to 1.08; ungraded).

1 finding from 1 review

1700 to 2200 ppm F toothpaste vs 440 to 550 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1700 to 2200 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 440 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

Cost‐effectiveness · Children aged 6 years and older (healthy except for dental caries)

In children aged 6 years and older, the cost-effectiveness estimate was extremely imprecise and not significant (OR 0.00, 95% CI 0.00 to 48704.6; ungraded).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste may leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

DMFT/DMFS index (dental caries experience) · Children aged 6 years and older (healthy except for dental caries)

In children aged 6 years and older, OHPPs showed no significant effect on DMFT/S (OR 0.29, 95% CI 0.08 to 1.01; ungraded).

1 finding from 1 review

1000 to 1250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1000 to 1250 ppm F toothpaste leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).

1 finding from 1 review

2400 to 2800 ppm F toothpaste vs 1450 to 1500 ppm F toothpaste

Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1450 to 1500 ppm F toothpaste (moderate certainty).

1 finding from 1 review

250 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

250 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).

1 finding from 1 review