Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

581 questions in 23 reviews · Implants and prosthodontics

current versions
No studies 87 · 15%Ungraded 388 · 66.8%Very low 88 · 15.1%Low 10 · 1.7%Moderate 8 · 1.4%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether
Number of intaglio adjustments · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture · 1 year
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
RR 1.43 [0.61, 3.34]1 study · 72 participantsVery low
Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method
Participant-reported quality of the denture (general satisfaction, VAS) · Completely edentulous people · 6 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
MD 0 [-8.23, 8.23]1 study · 105 participantsVery low
Ball (stud) attachment system vs Bar attachment system
Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
Only Walton 2002 assessed patient satisfaction but reported narrative results and failed to provide any usable numbers. Quality of life as assessed by a validated measure was not recorded in any of the trials.1 studyUngraded
Ball (stud) attachment system vs Telescopic attachment system
Cost (treatment time and/or material costs) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
no estimate extractedNRNo studies
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether
Operator-assessed gingival health of abutment · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture · 1 year, right abutment
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
RR 1.05 [0.56, 1.98]1 studyVery low
Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)
Participant-reported quality of the denture (comfort, stability, chewing efficiency) · Completely edentulous people · 2 weeks
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
The study reported that there was no difference between groups for comfort, but that more participants reported better stability and chewing efficiency with silicone. Data were not amenable to analysis.1 studyUngraded
Ball (stud) attachment system vs Telescopic attachment system
Prosthodontic maintenance: patrix replaced (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) · Short term (1 to 3 years)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
RR 6.00 [0.86, 41.96]1 study · 22 participantsVery low
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether
Participant-reported oral health-related quality of life · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
Not measured0 studiesNo studies
Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method
Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 6 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
MD 0.5 [-2.67, 3.67]1 study · 39 participantsVery low
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether
Abutment mobility · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture · 1 year, left abutment
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
RR 1.16 [0.40, 3.37]1 studyVery low
Ball (stud) attachment system vs Telescopic attachment system
Prosthodontic maintenance: matrix activated (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) · Short term (1 to 3 years)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
RR 11.00 [0.68, 177.72]1 study · 22 participantsVery low
Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)
Participant-reported oral health-related quality of life (OHIP-EDENT; lower score = better) · Completely edentulous people · 2 weeks
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
MD 7.20 [2.71, 11.69]1 study · 144 participantsLow
Tooth-supported removable partial denture: same impression material, different final-impression technique vs The same material with an alternative final-impression technique
Outcome NR · Partially edentulous people requiring a removable partial denture
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
We did not find any trials for this comparison.0 studiesNo studies
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether
Abutment mobility · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture · 1 year, right abutment
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
RR 2.90 [0.87, 9.61]1 studyVery low
Ball (stud) attachment system vs Bar attachment system
Prosthodontic maintenance (general categorization) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) · Short term (1 to 3 years)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
Recorded by Kappel 2016 and Walton 2002; they did not provide usable data for inclusion in the review.2 studiesUngraded
Wax (fluid wax), two stage-two step selective pressure final impression vs Polysulfide rubber (elastomer)
Number of border adjustments and sore spots after insertion of denture · Completely edentulous people · 1 year
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
RR 0.81 [0.38, 1.70]1 study · 27 participantsVery low
Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method
Mandibular denture satisfaction · Completely edentulous people · 6 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
SMD 0.21 [-0.11, 0.52]2 studies · 155 participantsVery low
Ball (stud) attachment system vs Telescopic attachment system
Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
Cepa 2017 assessed patient satisfaction but did not use validated measures and we could not use the data. Quality of life as assessed by a validated measure was not recorded.1 studyUngraded
Tooth-supported removable partial denture: different impression material, same final-impression technique vs The same technique with an alternative final-impression material
Outcome NR · Partially edentulous people requiring a removable partial denture
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
We did not find any trials for this comparison.0 studiesNo studies
Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method
Maxillary denture satisfaction · Completely edentulous people · 6 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
SMD -0.02 [-0.34, 0.29]2 studies · 155 participantsVery low
Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method
Participant-reported oral health-related quality of life (OHIP-EDENT) · Completely edentulous people · 1 month
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
MD 0.05 [-2.37, 2.47]2 studies · 98 participantsVery low
Ball (stud) attachment system vs Magnetic attachment system
Patient satisfaction / quality of life (validated measure) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
Two trials (Cune 2010; Naert 1999) reported patient satisfaction. However, we could not use any data from these studies. Quality of life as assessed by a validated measure was not recorded in any of the trials.2 studiesUngraded
Ball (stud) attachment system vs Magnetic attachment system
Prosthodontic maintenance (general categorization) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
Recorded by Cristache 2014, Cune 2010 and Naert 1999; they did not provide usable data for inclusion in the review.3 studiesUngraded
Any attachment system for maxillary implant overdentures vs A different attachment system for maxillary implant overdentures
Outcome NR · Edentulous adults receiving maxillary implant overdentures
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
no estimate extractedNRNo studies
Ball (stud) attachment system vs Magnetic attachment system
Re-treatment: repair of attachment system (medium term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) · Medium term (3 to 5 years)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
RR 1.75 [0.65, 4.72]1 study · 69 participantsVery low
Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)
Participant preference for dentures · Completely edentulous people · 2 weeks
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
Silicone impressions 57.7% (41 participants), alginate impressions 23.9% (17 participants); both equally satisfactory for 7 (9.9%) and equally unsatisfactory for 6 (8.5%) (McNemar chi-square 12.02, 1 df, P = 0.0005).1 study · 71 participantsUngraded
Ball (stud) attachment system vs Telescopic attachment system
Prosthodontic maintenance: reline of implant overdenture (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) · Short term (1 to 3 years)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
RR 2.33 [0.81, 6.76]1 study · 22 participantsVery low
Ball (stud) attachment system vs Telescopic attachment system
Prosthodontic maintenance: matrix replaced (short term) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures) · Short term (1 to 3 years)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
RR 1.75 [0.71, 4.31]1 study · 22 participantsVery low
Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method
Operator-assessed quality of the denture (retention and stability) · Completely edentulous people · 3 to 6 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
There was insufficient evidence of a clear difference between groups for operator-assessed quality of the dentures for retention and stability of dentures (Regis 2013).1 studyUngraded
Altered-cast impression technique (ACIP), polyether vs One-piece cast technique (OPC), polyether
Participant-reported quality of the denture (general satisfaction) · Partially edentulous people requiring a tooth- and tissue-supported (distal-extension) removable partial denture · 1 year
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
The study reported that 50 of 57 participants were moderately to completely satisfied, with no significant difference between the groups. Data not reported separately for each group.1 study · 57 participantsLow
Ball (stud) attachment system vs Magnetic attachment system
Patient preference (cross-over trials) · Edentulous adults receiving mandibular implant overdentures (opposing conventional complete maxillary dentures)
Interventions for replacing missing teeth: attachment systems for implant overdentures in edentulous jaws (2018) · Cochrane
no estimate extractedNRNo studies
Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer
Participant-reported quality of the denture (denture satisfaction, VAS) · Completely edentulous people · 3 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
VAS median scores: BPS 86.5; CCD 88. No clear difference between groups1 study · 10 participantsVery low
Biofunctional Prosthetic System (BPS): closed-mouth two stage-two step final impression with addition silicone elastomer vs Conventional complete denture technique (CCD): open-mouth two stage-two step conventional technique using elastomer
Participant preference for dentures · Completely edentulous people · 3 months
Final‐impression techniques and materials for making complete and removable partial dentures (2018) · Cochrane
When participants were asked which denture they would prefer to use long term, nine out of 10 opted for the one made with the BPS complete denture technique.1 study · 10 participantsUngraded
Metal-free implant-supported FDPs (zirconia-toughened alumina; In-Ceram Zirconia) vs Metal-free implant-supported FDPs (yttria-stabilized tetragonal zirconia; Denzir)
Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
No data were presented for any of the pre-specified secondary outcomes. Follow-up visits registered pocket depth, bleeding on probing and mobility but the data were not reported.0 studiesNo studies
Metal-free FDPs (lithium disilicate) vs Metal-ceramic FDPs
Aesthetic evaluation · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
No data were presented with regard to aesthetics.0 studiesNo studies
Metal-free FDPs (zirconia ceramic) vs Metal-ceramic FDPs
Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP) · 12 and 36 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
At 12 months and at 36 months 34 participants were available for analysis. No FDP failure was reported in either treatment approach at either time.1 study · 34 participantsVery low
Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)
Marginal bone level change (MBLC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown on… · 12 months, Distal
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
MD -0.05 [-0.15, 0.04]2 studies · 47 participantsUngraded
Metal-free implant-supported FDPs (zirconia-toughened alumina; In-Ceram Zirconia) vs Metal-free implant-supported FDPs (yttria-stabilized tetragonal zirconia; Denzir)
Bridge complications · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region · 60 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
OR 0.02 [0.00, 0.42]1 study · 18 participantsVery low
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs
Plaque index (PI) · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis · 24 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
MD -0.10 [-1.04, 0.84]1 study · 19 participantsUngraded
Metal-free single crowns (full-contour zirconia) vs Cast gold (conventional metal) single crowns
Crown failure · Adults (18 years or older) needing a single crown in the molar or premolar region · 12 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
OR 0.83 [0.05, 13.44]1 study · 194 participantsVery low
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs
Cantilevered bridge failure · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis · 12, 24 and 36 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
At 12 months 19 participants were available; no failure and no complication were reported in either group. No failure was reported at 24 or 36 months.1 study · 19 participantsVery low
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs
Gingival index (GI) · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis · 24 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
MD 0.03 [-0.75, 0.81]1 study · 19 participantsUngraded
Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns
Marginal bone level (first bone to implant contact, FBIC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown · 24 months, Mesial to crown
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
MD -0.01 [-0.93, 0.91]1 study · 18 participantsUngraded
Metal-free tooth-supported FDPs (pressed veneering ceramic) vs Metal-free tooth-supported FDPs (layered veneering ceramic)
Aesthetic evaluation · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
No comparative data were presented with regard to aesthetics. Aesthetics evaluated by the patient was reported dichotomously (yes/no) in the trial but no between-group estimate was presented.1 studyUngraded
Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)
Gingival/mucosal recession (REC) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown on… · 12 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
MD 0.00 [-0.22, 0.22]2 studies · 47 participantsUngraded
Metal-free tooth-supported FDPs (pressed veneering ceramic) vs Metal-free tooth-supported FDPs (layered veneering ceramic)
Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit tooth-supported fixed dental prosthesis
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
No comparative data were presented for the pre-specified secondary outcomes. The trial analyzed and reported plaque index, bleeding on probing and pocket probing depth but no between-group estimate was presented in the…1 studyUngraded
Metal-free implant abutments (zirconia) vs Metal implant abutments (titanium)
Abutment failure · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown on… · 12 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
OR 7.63 [0.33, 177.14]2 studies · 47 participantsVery low
Metal-free FDPs (zirconia ceramic) vs Metal-ceramic FDPs
Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
No data were presented for any of the pre-specified secondary outcomes. The trial registered pocket depth, bleeding on probing and mobility at follow-up visits but did not report the data.0 studiesNo studies
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) vs Metal-ceramic cantilevered FDPs
Cantilevered bridge complications · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis · 24 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
OR 5.59 [0.23, 133.61]1 study · 19 participantsVery low
Metal-free implant-supported single crowns (zirconia veneered with feldspathic ceramic) vs Metal-ceramic implant-supported single crowns
Aesthetic evaluation (patient satisfaction VAS) · Adults (18 years or older) with one missing tooth in the aesthetic zone needing an implant-supported single crown · 12 months
Metal‐free materials for fixed prosthodontic restorations (2017) · Cochrane
MD -4.65 [-18.75, 9.45]1 study · 18 participantsVery low