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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
473 questions in 36 reviews · HIV/AIDS
current versionsNo studies 38 · 8%Ungraded 9 · 1.9%Very low 126 · 26.6%Low 127 · 26.8%Moderate 152 · 32.1%High 21 · 4.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
An extended NVP plus ZDV regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week) HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.73 [0.6, 0.9] | 1 study · 1123 participants | Moderate |
An extended NVP plus ZDV regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week) Infants with any Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.75 [1.22, 2.53] | 1 study · 2000 participants | Very low |
An extended NVP plus ZDV regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week) Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 3.02 [0.61, 14.92] | 1 study · 2000 participants | Very low |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 1.23 [0.83, 1.81] | 1 study · 2013 participants | Moderate |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.91 [0.61, 1.36] | 1 study · 2013 participants | Moderate |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants HIV Transmission at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 1.04 [0.71, 1.51] | 1 study · 1122 participants | Moderate |
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1week) Infant Mortality at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.72 [0.5, 1.05] | 1 study · 2019 participants | Moderate |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 1.09 [0.82, 1.44] | 1 study · 2013 participants | Moderate |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.91 [0.61, 1.36] | 1 study · 1273 participants | Moderate |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 1 [0.75, 1.34] | 1 study · 1122 participants | Moderate |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants Infants with any Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.66 [1.16, 2.37] | 1 study · 2013 participants | Low |
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers1 Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.02 [0.33, 3.15] | 1 study · 2013 participants | Very low |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP HIV Transmission at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.78 [0.57, 1.07] | 1 study · 1887 participants | Moderate |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP Infant Mortality at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.47 [0.26, 0.84] | 1 study · 1887 participants | Low |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.72 [0.54, 0.95] | 1 study · 1887 participants | Moderate |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP Genotypic Resistance to NVP among Ugandan infants HIV‐infected at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.68 [1.09, 2.6] | 1 study · 49 participants | Low |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP Persistance of Genotypic Resistance to NVP at 6 months among Ugandan infants found to be resistant at 6 weeks ViroSeq · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 4.38 [1.05, 18.28] | 1 study · 13 participants | Low |
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1week) HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.69 [0.55, 0.87] | 1 study · 2019 participants | High |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP Genotypic Resistance to NVP among Indian infants HIV‐infected in utero or through peripartum/early‐breastfeeding transmission Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 2.42 [1.47, 3.97] | 1 study · 41 participants | Low |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP Genotypic Resistance to NVP among Indian infants HIV‐infected through late breastfeeding Standard Population Sequencing · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.03 [0.2, 5.33] | 1 study · 33 participants | Low |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP HIV Transmission at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.89 [0.67, 1.17] | 1 study · 1813 participants | Moderate |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP Infant Mortality at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.53 [0.32, 0.85] | 1 study · 2350 participants | Moderate |
An extended NVP regimen administered to infants for 6 weeks vs sdNVP HIV Transmission or Death at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.79 [0.61, 1.01] | 1 study · 1883 participants | Moderate |
Intervention NR HIV Transmission at 7 months among those whose HIV diagnostic testing was negative at one month after birth · breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 4.77 [2.22, 10.24] | 1 study · 1123 participants | Very low |
Intervention NR Infant Mortality at 18 months · breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.73 [0.49, 1.08] | 1 study · 1179 participants | Very low |
Intervention NR HIV Transmission or Death at 18 months among those whose HIV diagnostic testing was negative at one month after birth · breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 1.21 [0.81, 1.8] | 1 study · 1123 participants | Very low |
Intervention NR Infants with Grade 3/4 Signs or Symptoms · breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.74 [0.56, 0.98] | 1 study · 1179 participants | Very low |
Intervention NR Infants with Grade 3/4 Laboratory Abnormalities · breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.7 [1.33, 2.17] | 1 study · 1179 participants | Very low |
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1week) HIV Transmission at 24 months among those uninfected at birth11 · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.6 [0.46, 0.78] | 1 study · 1129 participants | Moderate |
Intervention NR Infant with Toxicity Events leading to cessation of ZDV · breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 5.53 [2.85, 10.74] | 1 study · 1179 participants | Very low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers HIV transmission at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.21 [0.01, 4.3] | 1 study · 548 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers Infant Mortality at 6 months · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.05 [0.37, 2.95] | 1 study · 553 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.81 [0.3, 2.14] | 1 study · 548 participants | Very low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers Infants with Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.13 [0.93, 1.37] | 1 study · 553 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers Maternal Mortality at 6 months · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.35 [0.01, 8.44] | 1 study · 560 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers Mothers with any Grade 3/4 Severe Adverse Event · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.79 [0.51, 1.21] | 1 study · 560 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers Mothers with Severe Adverse Events Requiring Treatment Modification · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.89 [0.3, 2.61] | 1 study · 560 participants | Very low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) HIV transmission at 6 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.36 [0.13, 1.02] | 1 study · 597 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) HIV transmission at 12 months among those whose diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.4 [0.16, 0.96] | 1 study · 597 participants | Low |
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1week) Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.74 [0.54, 1.01] | 1 study · 1266 participants | Moderate |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) Infant Mortality at 6 months · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.88 [0.36, 2.11] | 1 study · 624 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) Infant Mortality at 12 months · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.94 [0.48, 1.85] | 1 study · 624 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) HIV transmission or Death at 6 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.61 [0.3, 1.24] | 1 study · 599 participants | Low |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) HIV transmission or Death at 12 months among those whose HIV diagnostic testing was negative at 6 weeks after birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | HR 0.52 [0.28, 0.93] | 1 study · 599 participants | Moderate |
An extended ZDV/3TC/LPV/r regimen administered to mothers vs short course ZDV (intrapartum ZDV/3TC/sdNVP) Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.19 [0.83, 1.7] | 1 study · 824 participants | Very low |
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis HIV transmission at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.52 [0.3, 0.89] | 1 study · 1435 participants | Moderate |
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis Infant mortality at 28 weeks among those whose diagnostic testing was negative at 2 weeks after birth · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.67 [0.31, 1.45] | 1 study · 1517 participants | Low |
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 0.61 [0.38, 0.96] | 1 study · 1435 participants | Moderate |
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis Infants with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 1.11 [0.86, 8.45] | 1 study · 1517 participants | Low |
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis Mothers with Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane | RR 2.19 [1.2, 4] | 1 study · 1517 participants | Low |