Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

64 questions · 65 findings · 2 reviews · Skin

No studies found 30 · 46.2%GRADE not reported 0 · 0%Very low 20 · 30.8%Low 13 · 20%Moderate 2 · 3.1%High 0 · 0%

Salicylic acid vs tretinoin

Participants' global self‐assessment of acne improvement Moderate to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne

Salicylic acid showed no clear difference in participants' global self‐assessment of acne improvement Moderate to… compared with tretinoin (low certainty).

1 finding from 1 review

Nicotinamide vs clindamycin

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · participants with acne

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with clindamycin (low certainty).

1 finding from 1 review

Nicotinamide vs erythromycin

Withdrawal for any reason (medium term: treatment duration from 5 to 8 weeks) · participants with acne

Nicotinamide showed no clear difference in withdrawal for any reason (medium term: treatment duration from 5 to… compared with erythromycin (low certainty).

1 finding from 1 review

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Participants' global self‐assessment of acne improvement Fair to good improvement (long term: treatment duration > 8 weeks) · participants with acne

Glycolic acid (alpha‐hydroxy acid) showed no clear difference in participants' global self‐assessment of acne improvement Fair to… compared with salicylic‐mandelic acid (low certainty).

1 finding from 1 review

Glycolic acid (alpha‐hydroxy acid) vs salicylic‐mandelic acid

Minor adverse events · participants with acne

It is very uncertain whether glycolic acid (alpha‐hydroxy acid) changes total number of participants who experienced at least one minor… compared with salicylic‐mandelic acid (very low certainty).

1 finding from 1 review

Azelaic acid vs benzoyl peroxide

Participants' global self‐assessment of acne improvement Good or very good improvement (long term: treatment duration > 8 weeks) · participants with acne

Azelaic acid probably leads to lower participants' global self‐assessment of acne improvement Good or… compared with benzoyl peroxide (moderate certainty).

1 finding from 1 review