Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

84 questions · 93 findings · 8 reviews · Headline outcomes only

No studies found 5 · 5.4%GRADE not reported 4 · 4.3%Very low 20 · 21.5%Low 44 · 47.3%Moderate 19 · 20.4%High 1 · 1.1%

Very potent vs potent topical corticosteroid

Clinician‐reported signs of eczema: IGA (number with cleared or marked improvement); short term (earliest time point within 1‐2 weeks) · adults with eczema

Very potent showed no clear difference in clinician‐reported signs of eczema: IGA (number with cleared or… compared with potent topical corticosteroid (low certainty).

1 finding from 1 review

Very potent vs potent topical corticosteroid

Local adverse events: skin thinning; end of treatment (1 to 3 weeks) · adults with eczema

It is very uncertain whether very potent changes local adverse events: skin thinning; end of treatment (day 11‐day 22) compared with potent topical corticosteroid (very low certainty).

1 finding from 1 review

Twice daily or more vs once daily topical corticosteroid

Clinician‐reported signs of eczema: IGA (number with cleared or marked improvement); short term (earliest time point within 1‐4 weeks) · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in clinician‐reported signs of eczema: IGA (number with cleared or… compared with once daily topical corticosteroid (moderate certainty).

1 finding from 1 review

Twice daily or more vs once daily topical corticosteroid

Patient‐reported symptoms of eczema · children and adults, most with moderate to severe eczema

Twice daily or more showed no clear difference in patient‐reported symptoms of eczema: PGA (number with cleared or… compared with once daily topical corticosteroid (low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Clinician‐reported signs of eczema: number of participants with one or more relapses (16‐20 weeks) · children and adults with mild to severe eczema

Weekend therapy probably leads to lower clinician‐reported signs of eczema: number of participants with one… compared with no topical corticosteroid (moderate certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Local adverse events: skin thinning; end of treatment (16‐20 weeks + 2‐4 weeks acute phase) · children and adults with mild to severe eczema

Weekend therapy may leads to lower local adverse events: skin thinning; end of treatment (16‐20 weeks +… compared with no topical corticosteroid (low certainty).

1 finding from 1 review

Weekend therapy vs no topical corticosteroids

Systemic adverse events: abnormal cortisol; end of treatment (16 weeks + 4 weeks acute phase) · children and adults with mild to severe eczema

It is very uncertain whether weekend therapy changes systemic adverse events: abnormal cortisol; end of treatment (16… compared with no topical corticosteroid (very low certainty).

1 finding from 1 review

Moderate‐potency vs mild‐potency topical corticosteroid

Local adverse events: skin thinning; end of treatment (2‐5 weeks) · children and adults with mild to severe eczema

Moderate‐potency may leads to lower local adverse events: skin thinning; end of treatment (2‐5 weeks) compared with mild‐potency topical corticosteroid (low certainty).

1 finding from 1 review

Moderate‐potency vs mild‐potency topical corticosteroid

Systemic adverse events: abnormal cortisol; end of treatment (1‐6 weeks) · children and adults with mild to severe eczema

It is very uncertain whether moderate‐potency changes systemic adverse events: abnormal cortisol; end of treatment (6‐28… compared with mild‐potency topical corticosteroid (very low certainty).

1 finding from 1 review