Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

275 questions · 279 findings · 32 reviews · Kidney and Transplant

No studies found 76 · 27.2%GRADE not reported 5 · 1.8%Very low 42 · 15.1%Low 105 · 37.6%Moderate 46 · 16.5%High 5 · 1.8%

Angiotensin‐converting enzyme inhibitors vs ACEi plus angiotensin receptor blockers

Micro‐ to macroalbuminuria Median · people with diabetes and kidney disease

It is very uncertain whether angiotensin‐converting‐enzyme inhibitors (ACEi) alone changes micro‐ to macroalbuminuria Median compared with ACEi plus angiotensin receptor blockers (very low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs ACEi plus angiotensin receptor blockers

Micro‐ to normoalbuminuria Median · people with diabetes and kidney disease

Angiotensin‐converting‐enzyme inhibitors (ACEi) alone showed no clear difference in micro‐ to normoalbuminuria Median compared with ACEi plus angiotensin receptor blockers (low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Transplant or graft survival · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes transplant or graft survival compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Delayed graft function · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes delayed graft function Time frame: 1 to 3 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

More intensive vs less intensive insulin therapy

Death: unknown time frame · pre‐existing and new‐onset diabetes in kidney transplant recipients

It is very uncertain whether more intensive changes death (any cause) Time frame: 1 to 5 years compared with less intensive insulin therapy (very low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Fatal or nonfatal stroke · people with diabetes and kidney disease

Angiotensin receptor blockers showed no clear difference in fatal or nonfatal stroke Median compared with placebo or no treatment (low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Fatal or nonfatal myocardial infarction · people with diabetes and kidney disease

Angiotensin receptor blockers showed no clear difference in fatal or nonfatal myocardial infarction Median compared with placebo or no treatment (low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Micro‐ to macroalbuminuria Median · people with diabetes and kidney disease

Angiotensin receptor blockers may leads to lower micro‐ to macroalbuminuria Median compared with placebo or no treatment (low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Micro‐ to normoalbuminuria Median · people with diabetes and kidney disease

It is very uncertain whether angiotensin receptor blockers changes micro‐ to normoalbuminuria Median compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Death (all causes) · people with diabetes and kidney disease

Angiotensin receptor blockers showed no clear difference in all‐cause death Median compared with placebo or no treatment (low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Cardiovascular mortality · people with diabetes and kidney disease

Angiotensin receptor blockers showed no clear difference in cardiovascular death Median compared with placebo or no treatment (low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo

Number of participants reporting an adverse event · adults with early (stage 1 to 3) non‐diabetic CKD

It is very uncertain whether angiotensin receptor blockers changes adverse events (number reporting an adverse event) compared with placebo (very low certainty).

1 finding from 1 review