Findings

What do systematic reviews say?

193 questions · 205 findings · 27 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 46 · 22.4%GRADE not reported 4 · 2%Very low 54 · 26.3%Low 50 · 24.4%Moderate 35 · 17.1%High 16 · 7.8%

Radiosurgery alone vs WBRT and radiosurgery

NeurocognitionNo. of participants: 403(3 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Radiosurgery alone vs WBRT and radiosurgery

Neurological functionNo. of participants: 544(3 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Radiosurgery alone vs WBRT and radiosurgery

Quality of lifeNo. of participants: 271(2 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Overall survival ( · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) showed no clear difference in overall survival ( compared with surgery followed by chemotherapy (PDS) (high certainty).

1 finding from 1 review

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced… 2021 · Cochrane Headline outcomes only
HR 0.96 [0.86, 1.08]
4 studies · 2000 participants
High

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

Progression‐free survival · women with advanced ovarian epithelial cancer

Neoadjuvant chemotherapy prior to interval surgery (NACT) showed no clear difference in progression‐free survival ( compared with surgery followed by chemotherapy (PDS) (moderate certainty).

1 finding from 1 review

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced… 2021 · Cochrane Headline outcomes only
HR 0.98 [0.88, 1.08]
4 studies · 1847 participants
Moderate

Neoadjuvant chemotherapy prior to interval surgery (NACT) vs surgery followed by chemotherapy (PDS)

EORTC QLQ‐C30 QoL at 6 months ‐ global health · women with advanced ovarian epithelial cancer

1 finding from 1 review

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 524 participants
Very low

iMRI image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

iMRI image‐guided surgery vs surgery

Overall survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

iMRI image‐guided surgery vs surgery

Progression‐free survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

iMRI image‐guided surgery vs surgery

Quality of life · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ALA image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ALA image‐guided surgery vs surgery

Overall survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ALA image‐guided surgery vs surgery

Progression‐free survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

5‐ALA image‐guided surgery vs surgery

Quality of life · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Neuronavigation image‐guided surgery vs surgery

Overall survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Neuronavigation image‐guided surgery vs surgery

Progression‐free survival · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Neuronavigation image‐guided surgery vs surgery

Quality of life · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Neuronavigation image‐guided surgery vs surgery

Adverse events · high‐grade glioma

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta‐analysis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Intraoperative imaging technology to maximise extent of resection for glioma 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Overall survival · Patients with brain metastases

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in overall survival compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases 2017 · Cochrane Headline outcomes only
HR 0.82 [0.65, 1.02]
2 studies · 358 participants
Moderate

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) vs WBRT

Disease‐specific survival · Patients with brain metastases

Whole brain radiation therapy (WBRT) + stereotactic radiosurgery (SRS) showed no clear difference in disease‐specific survival compared with WBRT (moderate certainty).

1 finding from 1 review

Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases 2017 · Cochrane Headline outcomes only
RR 0.92 [0.64, 1.32]
1 study · 286 participants
Moderate