Findings

What do systematic reviews say?

141 questions · 144 findings · 5 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 69 · 47.9%GRADE not reported 9 · 6.3%Very low 13 · 9%Low 28 · 19.4%Moderate 16 · 11.1%High 9 · 6.3%

Summary of findings: Endorectal balloon vs no intervention

Mean GI symptom scores · Men undergoing RT for prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Endorectal balloon vs no intervention

Acute and late GI toxicity (grade 2+) · Men undergoing RT for prostate cancer

It is very uncertain whether summary of findings: Endorectal balloon changes acute and late GI toxicity (grade 2+) compared with no intervention (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 1 [0.41, 2.42]
1 study · 48 participants
Very low

Summary of findings: Endorectal balloon vs no intervention

Diarrhoea (grade 2+) · Men undergoing RT for prostate cancer

It is very uncertain whether summary of findings: Endorectal balloon changes diarrhoea (grade 2+) compared with no intervention (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.71 [0.37, 1.35]
1 study · 43 participants
Very low

Summary of findings: Endorectal balloon vs no intervention

QoL · Men undergoing RT for prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Proteolytic enzymes vs placebo or control

Mean GI symptom scores · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Proteolytic enzymes vs placebo or control

Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer

Summary of findings: Proteolytic enzymes may leads to lower acute and late GI toxicity (grade 2+) compared with control (placebo or no intervention) (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.45 [0.24, 0.88]
1 study · 120 participants
Low

Summary of findings: Proteolytic enzymes vs placebo or control

Diarrhoea (grade 2+) · People undergoing RT for pelvic cancer

It is very uncertain whether summary of findings: Proteolytic enzymes changes diarrhoea (grade 2+) compared with control (placebo or no intervention) (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 1.6 [0.89, 2.89]
1 study · 56 participants
Very low

Summary of findings: Proteolytic enzymes vs placebo or control

QoL · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Protein supplements vs no intervention

Mean GI symptom scores (lower is better) · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Protein supplements vs no intervention

Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Protein supplements vs no intervention

Diarrhoea (grade 2+) · People undergoing RT for pelvic cancer

It is very uncertain whether summary of findings: Protein supplements changes diarrhoea (grade 2+) compared with no intervention (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.53 [0.27, 1.03]
1 study · 74 participants
Very low

Summary of findings: Protein supplements vs no intervention

QoL · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Superoxide dismutase (SOD) vs no intervention

Mean GI symptom scores · people with Rectal Cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Superoxide dismutase (SOD) vs no intervention

Acute and late GI toxicity (grade 2+) · people with Rectal Cancer

Summary of findings: Superoxide dismutase may leads to lower acute and late GI toxicity (grade 2+) compared with no intervention (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.2 [0.05, 0.86]
1 study · 92 participants
Low

Superoxide dismutase (SOD) vs no intervention

Diarrhoea (grade 2+) · people with Rectal Cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Superoxide dismutase (SOD) vs no intervention

QoL · people with Rectal Cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Bile acid sequestrants vs no intervention

Mean GI symptom scores (during RT) · People with pelvic cancer

It is very uncertain whether summary of findings: Bile acid sequestrants changes mean GI symptom scores (during RT) compared with no intervention (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
MD 0.5
1 study · 33 participants
Very low

Summary of findings: Bile acid sequestrants vs no intervention

Acute and late GI toxicity (grade 2+) · People with pelvic cancer

Summary of findings: Bile acid sequestrants may leads to higher acute and late GI toxicity (grade 2+) compared with no intervention (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 4.24 [1.07, 16.7]
1 study · 33 participants
Low

Summary of findings: Bile acid sequestrants vs no intervention

Diarrhoea (grade 2+) · People with pelvic cancer

It is very uncertain whether summary of findings: Bile acid sequestrants changes diarrhoea (grade 2+) compared with no intervention (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 2.82 [0.66, 12.01]
1 study · 33 participants
Very low

Summary of findings: Bile acid sequestrants vs no intervention

QoL · People with pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found