Summary of findings: punctal plugs vs artificial tears
Tear film stability · adults with dry eye syndrome
1 finding from 1 review
- no estimate extractedStudies not reportedModerate
Findings
What do systematic reviews say?
189 questions · 190 findings · 12 reviews · Eyes and Vision
No studies found 57 · 30%GRADE not reported 4 · 2.1%Very low 53 · 27.9%Low 33 · 17.4%Moderate 28 · 14.7%High 15 · 7.9%
Summary of findings: punctal plugs vs artificial tears
Artificial tear use · adults with dry eye syndrome
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings: punctal plugs vs artificial tears
Adverse events (punctate epithelial keratopathy) · adults with dry eye syndrome
Summary of findings: punctal plugs showed no clear difference in adverse events (punctate epithelial keratopathy) compared with artificial tears (low certainty).
1 finding from 1 review
- RR 1.33 [0.57, 3.12]Studies not reportedLow
Summary of findings: punctal plugs vs no punctal plugs
Aqueous tear production · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted1 study · 28 participantsLow
Summary of findings: punctal plugs vs no punctal plugs
Tear film stability · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted1 study · 28 participantsLow
Summary of findings: punctal plugs vs no punctal plugs
Artificial tear use · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted1 study · 61 participantsLow
Summary of findings: punctal plugs vs no punctal plugs
Adverse events · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted4 studies · 146 participantsVery low
Summary of findings: punctal plugs vs cyclosporine A
Symptomatic improvement · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted2 participantsGRADE not reported
Summary of findings: punctal plugs vs cyclosporine A
Ocular surface staining · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Summary of findings: punctal plugs vs cyclosporine A
Aqueous tear production · adults with dry eye syndrome
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Rituximab vs intravenous methylprednisolone
CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy
Summary of findings table ‐ Rituximab showed no clear difference in CAS improvement (decrease) by 2 or more points compared with intravenous methylprednisolone (low certainty).
1 finding from 1 review
- RR 1.32 [0.98, 1.78]1 study · 31 participantsLow
Rituximab vs placebo
Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy
It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with placebo (very low certainty).
1 finding from 1 review
- RR 0.46 [0.1, 2.08]1 study · 25 participantsVery low
Rituximab vs placebo
Palpebral aperture change · thyroid‐associated ophthalmopathy
1 finding from 1 review
- no estimate extracted1 study · 25 participantsVery low
Rituximab vs placebo
Motility · thyroid‐associated ophthalmopathy
1 finding from 1 review
- no estimate extracted1 study · 25 participantsVery low
Rituximab vs placebo
Quality of life · thyroid‐associated ophthalmopathy
1 finding from 1 review
- no estimate extracted1 study · 25 participantsVery low
Rituximab vs placebo
Adverse effects · thyroid‐associated ophthalmopathy
It is very uncertain whether summary of findings table ‐ Rituximab changes adverse effects compared with placebo (very low certainty).
1 finding from 1 review
- RR 2.46 [0.84, 7.18]1 study · 25 participantsVery low
Rituximab vs intravenous methylprednisolone
NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy
It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 or more classes compared with intravenous methylprednisolone (very low certainty).
1 finding from 1 review
- RR 1.07 [0.25, 4.49]1 study · 31 participantsVery low
Rituximab vs intravenous methylprednisolone
Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy
It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with intravenous methylprednisolone (very low certainty).
1 finding from 1 review
- RR 0.35 [0.02, 8.08]1 study · 31 participantsVery low
Rituximab vs intravenous methylprednisolone
Palpebral aperture improvement (decrease) by 3 mm or more · thyroid‐associated ophthalmopathy
It is very uncertain whether summary of findings table ‐ Rituximab changes palpebral aperture improvement (decrease) by 3 mm or more compared with intravenous methylprednisolone (very low certainty).
1 finding from 1 review
- RR 5.31 [0.28, 102.38]1 study · 31 participantsVery low
Rituximab vs intravenous methylprednisolone
Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy
It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).
1 finding from 1 review
- RR 1.07 [0.25, 4.49]1 study · 31 participantsVery low