Findings

What do systematic reviews say?

58 questions · 66 findings · 7 reviews · Airways

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No studies found 3 · 4.5%GRADE not reported 2 · 3%Very low 14 · 21.2%Low 17 · 25.8%Moderate 20 · 30.3%High 10 · 15.2%

Vitamin C vs placebo

Asthma exacerbations · people with asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Vitamin C vs placebo

Lung function: FEV1 mL (change from baseline) · people with asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 201 participants
Moderate

Vitamin C vs placebo

Asthma symptoms · people with asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 201 participants
Moderate

Vitamin C vs placebo

Adverse events · people with asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low

Vitamin C vs placebo

Health‐related quality of life (HRQL) · adults and children with exercise‐induced bronchoconstriction/asthma

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin C vs placebo

Asthma exacerbations · adults and children with exercise‐induced bronchoconstriction/asthma

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Vitamin C vs placebo

Lung function: FEV1 % drop Postexercise · adults and children with exercise‐induced bronchoconstriction/asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8 participants
Low

Vitamin C vs placebo

Asthma symptoms · adults and children with exercise‐induced bronchoconstriction/asthma

1 finding from 1 review

Vitamin C for asthma and exercise‐induced bronchoconstriction 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 8 participants
Low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in arterial partial pressure of oxygen · stable COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 271 participants
Moderate
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 171 participants
Low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in arterial partial pressure of oxygen · post‐exacerbation COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 234 participants
Low
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 170 participants
Low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in arterial partial pressure of carbon dioxide · post‐exacerbation COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 241 participants
Moderate
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 175 participants
High

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Change in the health‐related quality of life · post‐exacerbation COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 219 participants
Very low
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 164 participants
Very low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

Admission‐free survival · post‐exacerbation COPD

Summary of Findings Table ‐ Chronic non‐invasive ventilation may leads to lower admission‐free survival compared with standard treatment following a severe exacerbation (low certainty).

1 finding from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
HR 0.71 [0.54, 0.94]
2 studies · 317 participants
Low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs standard treatment following a severe exacerbation

All‐cause mortality · post‐exacerbation COPD

Summary of Findings Table ‐ Chronic non‐invasive ventilation showed no clear difference in all‐cause mortality compared with standard treatment following a severe exacerbation (low certainty).

1 finding from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
HR 0.97 [0.74, 1.28]
2 studies · 318 participants
Low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in arterial partial pressure of carbon dioxide · stable COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 475 participants
High
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 232 participants
High

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in 6‐minute walking distance · stable COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 330 participants
Low
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 134 participants
Very low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

Change in the health‐related quality of life · stable COPD

2 findings from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 259 participants
Very low
Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 200 participants
Very low

Summary of Findings Table ‐ Chronic non‐invasive ventilation vs usual care

All‐cause mortality · stable COPD

Summary of Findings Table ‐ Chronic non‐invasive ventilation probably leads to lower all‐cause mortality compared with standard treatment (moderate certainty).

1 finding from 1 review

Chronic non‐invasive ventilation for chronic obstructive pulmonary disease 2021 · Cochrane Headline outcomes only
HR 0.75 [0.58, 0.97]
3 studies · 405 participants
Moderate