Findings

What do systematic reviews say?

122 questions · 126 findings · 21 reviews · Headline outcomes only

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No studies found 23 · 18.3%GRADE not reported 1 · 0.8%Very low 26 · 20.6%Low 44 · 34.9%Moderate 30 · 23.8%High 2 · 1.6%

Methadone vs oral slow‐release morphine

Birthweight (g) · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Methadone vs oral slow‐release morphine

APGAR score (APGAR score ) · opiate‐dependent pregnant women

The review found no eligible studies for this question.

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Methadone vs oral slow‐release morphine

Adverse events for the mother · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Methadone vs oral slow‐release morphine

Serious adverse events for the child · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Methadone vs oral slow‐release morphine

Unacceptability of treatment (dropouts/exclusions during the trial) · opiate‐dependent pregnant women

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Low

Methadone vs oral slow‐release morphine

Use of substance · opiate‐dependent pregnant women

Methadone showed no clear difference in use of substance compared with oral slow‐release morphine (low certainty).

1 finding from 1 review

Maintenance agonist treatments for opiate‐dependent pregnant women 2020 · Cochrane Headline outcomes only
RR 2.4 [1, 5.77]
1 study · 48 participants
Low

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Live birth rate per woman · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes live birth per woman randomly assigned compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Advanced sperm selection techniques for assisted reproduction 2019 · Cochrane Headline outcomes only
RR 1.13 [0.64, 2.01]
1 study · 100 participants
Very low

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Miscarriage · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes miscarriage per woman randomly assigned compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Advanced sperm selection techniques for assisted reproduction 2019 · Cochrane Headline outcomes only
RR 0.8 [0.23, 2.81]
1 study · 100 participants
Very low

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Miscarriage per clinical pregnancy · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes miscarriage per clinical pregnancy compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Advanced sperm selection techniques for assisted reproduction 2019 · Cochrane Headline outcomes only
RR 0.76 [0.24, 2.44]
1 study · 41 participants
Very low

Hyaluronic acid‐selected sperm (HA‐ICSI) vs viscous medium containing HA (SpermSlow)

Clinical pregnancy · assisted reproduction

It is very uncertain whether hyaluronic acid‐selected sperm (HA‐ICSI) changes clinical pregnancy per woman randomly assigned compared with viscous medium containing HA (SpermSlow) (very low certainty).

1 finding from 1 review

Advanced sperm selection techniques for assisted reproduction 2019 · Cochrane Headline outcomes only
RR 1.05 [0.66, 1.68]
1 study · 100 participants
Very low

Rapid vs slow taper of buprenorphine dose

Completion of withdrawal treatment − Outpatient · Adults or adolescents with opioid dependence

It is very uncertain whether rapid changes completion of withdrawal treatment − Outpatient compared with slow taper of buprenorphine dose (very low certainty).

1 finding from 1 review

Buprenorphine for managing opioid withdrawal 2017 · Cochrane Headline outcomes only
RR 0.86 [0.44, 1.7]
4 studies · 647 participants
Very low

Rapid vs slow taper of buprenorphine dose

Abstinents at · Adults or adolescents with opioid dependence

Rapid showed no clear difference in number abstinent at completion of dose taper − Inpatient compared with slow taper of buprenorphine dose (low certainty).

1 finding from 1 review

Buprenorphine for managing opioid withdrawal 2017 · Cochrane Headline outcomes only
RR 1 [0.81, 1.23]
1 study · 40 participants
Low

Rapid vs slow taper of buprenorphine dose

Number abstinent at completion of dose taper − Outpatient · Adults or adolescents with opioid dependence

It is very uncertain whether rapid changes number abstinent at completion of dose taper − Outpatient compared with slow taper of buprenorphine dose (very low certainty).

1 finding from 1 review

Buprenorphine for managing opioid withdrawal 2017 · Cochrane Headline outcomes only
RR 0.94 [0.39, 2.24]
4 studies · 619 participants
Very low

Rapid vs slow taper of buprenorphine dose

Completion of withdrawal treatment − Inpatient · Adults or adolescents with opioid dependence

Rapid showed no clear difference in completion of withdrawal treatment − Inpatient compared with slow taper of buprenorphine dose (low certainty).

1 finding from 1 review

Buprenorphine for managing opioid withdrawal 2017 · Cochrane Headline outcomes only
RR 1 [0.84, 1.18]
2 studies · 60 participants
Low

Fast absorbable vs slow absorbable sutures

Incisional hernia · patients undergoing a laparotomy incision

Fast absorbable showed no clear difference in incisional hernia compared with slow absorbable sutures (moderate certainty).

1 finding from 1 review

Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications 2017 · Cochrane Headline outcomes only
RR 0.81 [0.63, 1.06]
10 studies · 3643 participants
Moderate

Fast absorbable vs slow absorbable sutures

Wound infection · patients undergoing a laparotomy incision

Fast absorbable showed no clear difference in wound infection at last compared with slow absorbable sutures (moderate certainty).

1 finding from 1 review

Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications 2017 · Cochrane Headline outcomes only
RR 1.16 [0.85, 1.57]
11 studies · 4100 participants
Moderate

Fast absorbable vs slow absorbable sutures

Wound dehiscence · patients undergoing a laparotomy incision

Fast absorbable showed no clear difference in wound dehiscence at last compared with slow absorbable sutures (moderate certainty).

1 finding from 1 review

Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications 2017 · Cochrane Headline outcomes only
RR 1.55 [0.92, 2.61]
8 studies · 3440 participants
Moderate

Fast absorbable vs slow absorbable sutures

Sinus or fistula formation at last · patients undergoing a laparotomy incision

It is very uncertain whether fast absorbable changes sinus or fistula formation at last compared with slow absorbable sutures (very low certainty).

1 finding from 1 review

Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications 2017 · Cochrane Headline outcomes only
RR 0.88 [0.05, 16.05]
2 studies · 911 participants
Very low

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
OR 0.72 [0.58, 0.9]
3 studies · 2445 participants
Moderate

Lutein with or without zeaxanthin vs placebo

Progression to geographic atrophy · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to geographic atrophy compared with placebo (low certainty).

1 finding from 1 review

Antioxidant vitamin and mineral supplements for slowing the progression of age‐related macular degeneration 2023 · Cochrane Headline outcomes only
RR 0.92 [0.8, 1.05]
1 study · 6891 participants
Low