Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

212 questions · 217 findings · 28 reviews · Headline outcomes only

No studies found 53 · 24.4%GRADE not reported 6 · 2.8%Very low 24 · 11.1%Low 69 · 31.8%Moderate 47 · 21.7%High 18 · 8.3%

Intervention not reported

After accounting for all potential confounders, the overall average effect of speed cameras on crashes was a reduction of 25% in personal injury crashes (PIA's) and an average 11% reduction in fatal and serious crashes for the 500m monitoring leng...
1 finding from 1 review

Tixagevimab/cilgavimab vs placebo

Infection with SARS‐CoV‐2 within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Tixagevimab/cilgavimab probably leads to lower infection with SARS‐CoV‐2 within 6 months compared with placebo (moderate certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab may leads to lower development of clinical COVID‐19 symptoms within 6 months compared with placebo (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Quality of life at longest · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

The review found no eligible studies for this question.

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Adverse events: grade 1 to 2 · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

The review found no eligible studies for this question.

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Grades 3 and 4 adverse events · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes adverse events: grade 3 to 4 within 6 months compared with placebo (very low certainty).

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Adverse events: all grades · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in adverse events: all grades within 6 months compared with placebo (low certainty).

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

It is very uncertain whether casirivimab/imdevimab changes serious adverse events within 6 months compared with placebo (very low certainty).

1 finding from 1 review

Tixagevimab/cilgavimab vs placebo

Development of clinical COVID‐19 symptoms within 6 months · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Tixagevimab/cilgavimab leads to lower development of clinical COVID‐19 symptoms within 6 months compared with placebo (high certainty).

1 finding from 1 review