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What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 674 findings · 79 reviews · Gut

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No studies found 116 · 17.2%GRADE not reported 14 · 2.1%Very low 133 · 19.7%Low 225 · 33.4%Moderate 145 · 21.5%High 41 · 6.1%

Corticosteroids vs placebo

Withdrawals due to adverse events · inactive EoE patients

Corticosteroids may leads to lower withdrawals due to adverse events 12 to 50 weeks compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Clinical improvement (dichotomous) · active EoE patients

Biologics showed no clear difference in clinical improvement (dichotomous) compared with placebo (low certainty).

1 finding from 1 review

Biologics vs placebo

Histological improvement (dichotomous) · active EoE patients

Biologics probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review

Biologics vs placebo

Withdrawals due to adverse events · active EoE patients

Biologics showed no clear difference in withdrawals due to adverse events 12 to 44 weeks compared with placebo (low certainty).

1 finding from 1 review

Cromolyn sodium vs placebo

Withdrawals due to adverse events · active EoE pediatric patients

Cromolyn sodium showed no clear difference in withdrawals due to adverse events at 8 weeks compared with placebo (low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Histological improvement (dichotomous) · active EoE patients

Corticosteroids leads to higher histological improvement (dichotomous) compared with placebo (high certainty).

1 finding from 1 review