Phenobarbital and opioid vs opioid
Days' pharmacological treatment · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
125 questions · 125 findings · 7 reviews
No studies found 44 · 35.2%GRADE not reported 1 · 0.8%Very low 52 · 41.6%Low 21 · 16.8%Moderate 7 · 5.6%High 0 · 0%
Phenobarbital and opioid vs opioid
Adverse events To discharge · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 18 months · children with febrile seizures
Continuous phenobarbital showed no clear difference in recurrent seizure at 18 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.77 [0.56, 1.05]2 studies · 264 participantsModerate
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 24 months · children with febrile seizures
Continuous phenobarbital probably leads to lower recurrent seizure at 24 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.69 [0.53, 0.89]3 studies · 533 participantsModerate
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 36 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 48 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 60 months or greater · children with febrile seizures
It is very uncertain whether continuous phenobarbital changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 1.5 [0.61, 3.69]1 study · 60 participantsVery low
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 6 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 12 months · children with febrile seizures
Continuous phenobarbital showed no clear difference in recurrent seizure at 12 months compared with intermittent rectal or oral diazepam (low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 1.48 [0.75, 2.94]1 study · 145 participantsLow
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 18 months · children with febrile seizures
It is very uncertain whether continuous phenobarbital changes recurrent seizure at 18 months compared with intermittent rectal or oral diazepam (very low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 1.25 [0.36, 4.38]1 study · 100 participantsVery low
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 24 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 36 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 48 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs intermittent rectal or oral diazepam
Recurrent seizure at 60 months or greater · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 6 months · children with febrile seizures
Continuous phenobarbital probably leads to lower recurrent seizure at 6 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.59 [0.42, 0.83]6 studies · 833 participantsModerate
Continuous phenobarbital vs placebo or no treatment
Recurrent seizure at 12 months · children with febrile seizures
Continuous phenobarbital may leads to lower recurrent seizure at 12 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.54 [0.42, 0.7]7 studies · 807 participantsLow
Intermittent phenobarbital vs placebo or no treatment
Recurrent seizure at 6 months · children with febrile seizures
It is very uncertain whether intermittent phenobarbital changes recurrent seizure at 6 months compared with placebo or no treatment (very low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 1.37 [0.67, 2.81]2 studies · 281 participantsVery low
Intermittent phenobarbital vs placebo or no treatment
Recurrent seizure at 12 months · children with febrile seizures
Intermittent phenobarbital showed no clear difference in recurrent seizure at 12 months compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 1.01 [0.65, 1.59]2 studies · 281 participantsModerate
Intermittent phenobarbital vs placebo or no treatment
Recurrent seizure at 18 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Intermittent phenobarbital vs placebo or no treatment
Recurrent seizure at 24 months · children with febrile seizures
Intermittent phenobarbital showed no clear difference in recurrent seizure at 24 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
- Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes onlyRR 0.85 [0.57, 1.28]1 study · 249 participantsLow