Findings

What do systematic reviews say?

43 questions · 45 findings · 14 reviews · Airways

Sort:Best matchNewest Highest certainty Download CSV

No studies found 4 · 8.9%GRADE not reported 3 · 6.7%Very low 4 · 8.9%Low 20 · 44.4%Moderate 12 · 26.7%High 2 · 4.4%

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 0.88 [0.74, 1.05]
9 studies · 2978 participants
Moderate

Antibiotics vs placebo

Any adverse event WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in any adverse event WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
OR 1.07 [0.69, 1.67]
4 studies · 512 participants
Moderate

Antibiotics vs placebo

FEV1 · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

1 finding from 1 review

Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 658 participants
Moderate