Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

63 questions · 63 findings · 3 reviews · Pregnancy and Childbirth

No studies found 7 · 11.1%GRADE not reported 0 · 0%Very low 24 · 38.1%Low 25 · 39.7%Moderate 7 · 11.1%High 0 · 0%

Oral misoprostol vs mechanical methods

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changes compared with mechanical methods (very low certainty).

1 finding from 1 review

Oral misoprostol vs placebo/no treatment

Uterine hyperstimulation without fetal heart rate changes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Oral misoprostol vs placebo/no treatment

Apgar score less than 7 at 5 minutes · women with ruptured membranes in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes apgar score less than 7 at 5 minutes compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Vaginal delivery not achieved within 24 hours · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) probably leads to higher vaginal delivery not achieved within 24 hours compared with low‐dose oral misoprostol (moderate certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Uterine hyperstimulation with fetal heart rate changes · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in uterine hyperstimulation with FHR changes compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review

Balloon (Foley or ATAD) vs low‐dose oral misoprostol

Serious neonatal morbidity or perinatal death · third trimester induction of labour in women with a viable fetus

Balloon (Foley or ATAD) showed no clear difference in serious neonatal morbidity or perinatal death compared with low‐dose oral misoprostol (low certainty).

1 finding from 1 review