Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

151 questions · 171 findings · 15 reviews

No studies found 26 · 15.2%GRADE not reported 21 · 12.3%Very low 52 · 30.4%Low 49 · 28.7%Moderate 20 · 11.7%High 3 · 1.8%

Primary school-based interventions (one or more of: school health policy, oral health education, healthy school environment, access to oral health services, community involvement) vs usual practice

Plaque index (PI) / oral hygiene · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)

School-based interventions may reduce dental plaque scores (SMD -0.32, favouring intervention), but the certainty of evidence is very low.

1 finding from 1 review

Primary school-based interventions (one or more of: school health policy, oral health education, healthy school environment, access to oral health services, community involvement) vs usual practice

Oral hygiene measured by mean gingival scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)

The effect of school-based interventions on gingival scores is uncertain and not statistically significant (SMD 0.12; very low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Iron deficiency at term (as defined by trialists, based on any indicator of iron status at 37 wk gestation or more) · pregnant women

(Maternal outcomes) Any supplements containing iron may leads to lower maternal iron deficiency at term (as defined by as defined by… compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Iron deficiency at term (as defined by trialists, based on any indicator of iron status at 37 wk gestation or more) · pregnant women

(Maternal outcomes) Any supplements containing iron and folic acid may leads to lower maternal iron deficiency at term (as defined by trialists, based on… compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review

Intravenous iron vs oral iron

All gastrointestinal symptoms Reported by the women · women with postpartum iron deficiency anaemia

It is very uncertain whether intravenous iron changes all gastrointestinal symptoms Reported by the women compared with oral iron (very low certainty).

1 finding from 1 review

Intravenous iron vs oral iron

Anaphylaxis or evidence of hypersensitivity Clinical assessment · women with postpartum iron deficiency anaemia

Intravenous iron showed no clear difference in anaphylaxis or evidence of hypersensitivity Clinical assessment compared with oral iron (low certainty).

1 finding from 1 review

Favorable socioeconomic and family environment vs Less favorable socioeconomic and family environment

Oral health-related quality of life · Adolescents (10-19 years)

The umbrella review reported better oral health-related quality of life with favorable housing, parental education, income, family environment, and access to dental care.

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and at least 1 additional laboratory indicators at 37 weeks' gestation or more) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review