Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

105 questions · 106 findings · 16 reviews · Schizophrenia

No studies found 20 · 18.9%GRADE not reported 7 · 6.6%Very low 40 · 37.7%Low 23 · 21.7%Moderate 9 · 8.5%High 7 · 6.6%

HALOPERIDOL vs OLANZAPINE

Specific behaviour ‐ threat or injury to self or others average change score (ABS, high = worse) at 2 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes specific behaviour ‐ threat or injury to self or others compared with OTHER ANTIPSYCHOTIC: e. OLANZAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OLANZAPINE

Global outcome ‐ need for benzodiazepine during 24 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome ‐ need for benzodiazepine during 24 hours compared with OTHER ANTIPSYCHOTIC: e. OLANZAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OLANZAPINE

Adverse effects: Specific ‐ dystonia during 24 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: e. OLANZAPINE (very low certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Tranquillisation or asleep: tranquillised/asleep ‐ by around 30 minutes · acute psychosis

Droperidol showed no clear difference in tranquillisation or asleep: tranquillised/asleep ‐ by around 30… compared with olanzapine (high certainty).

1 finding from 1 review

Droperidol vs OLANZAPINE

Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis

Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with olanzapine (high certainty).

1 finding from 1 review