Findings

What do systematic reviews say?

45 questions · 58 findings · 2 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 10 · 17.2%GRADE not reported 0 · 0%Very low 24 · 41.4%Low 0 · 0%Moderate 15 · 25.9%High 9 · 15.5%

Altered WBRT fractionation schedules vs WBRT control

Symptom controlNo. of participants: 1814(3 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Altered WBRT fractionation schedules vs WBRT control

Overall brain controlNo. of participants: 203(2 RCTs) · patients with newly diagnosed multiple brain metastases

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Neurological function improvement: lower‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1612(5 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher neurological function improvement: lower‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
OR 1.74 [1.06, 2.84]
Studies not reported
Moderate

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Neurological function improvement: higher‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1480(4 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules showed no clear difference in neurological function improvement: higher‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
OR 1.14 [0.92, 1.42]
Studies not reported
Moderate

WBRT with radiosensitisers (radiosen) vs WBRT

Overall survivalNo. of participants: 2631(8 RCTs) · patients with newly diagnosed multiple brain metastases

WBRT with radiosensitisers (radiosen) showed no clear difference in overall survivalNo. of participants: 2631(8 RCTs) compared with WBRT alone (moderate certainty).

1 finding from 1 review

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases 2018 · Cochrane Headline outcomes only
HR 1.05 [0.99, 1.12]
Studies not reported
Moderate