Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

178 questions · 186 findings · 8 reviews

No studies found 40 · 21.5%GRADE not reported 3 · 1.6%Very low 14 · 7.5%Low 75 · 40.3%Moderate 32 · 17.2%High 22 · 11.8%

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review