Findings

What do systematic reviews say?

48 questions · 48 findings · 1 reviews · Skin

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No studies found 14 · 29.2%GRADE not reported 1 · 2.1%Very low 0 · 0%Low 10 · 20.8%Moderate 12 · 25%High 11 · 22.9%

Topical ivermectin vs topical metronidazole

Physician‐assessed improvement in rosacea severity · Participants with rosacea

Topical ivermectin leads to higher physician‐assessed improvement in rosacea severity compared with topical metronidazole (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 1.13 [1.06, 1.2]
1 study · 962 participants
High

Topical ivermectin vs topical metronidazole

Assessment of erythema or telangiectasia ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical ivermectin vs topical metronidazole

Lesion count · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 962 participants
High

Topical ivermectin vs topical metronidazole

Time needed until improvement of the skin lesions · Participants with rosacea

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 962 participants
High

Topical ivermectin vs topical metronidazole

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in participant‐assessed improvement in rosacea severity Excellent… compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 1.05 [0.79, 1.4]
1 study · 207 participants
High

Doxycycline 40 mg + azelaic acid gel vs doxycycline 40 mg + metronidazole gel

Proportion of participants with adverse event · Participants with rosacea

Doxycycline 40 mg + azelaic acid gel showed no clear difference in proportion of participants with adverse event compared with doxycycline 40 mg + metronidazole gel (high certainty).

1 finding from 1 review

Interventions for rosacea 2015 · Cochrane Headline outcomes only
RR 0.27 [0.06, 1.28]
1 study · 207 participants
High