Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

231 questions · 245 findings · 9 reviews · Gut

No studies found 76 · 31%GRADE not reported 3 · 1.2%Very low 106 · 43.3%Low 47 · 19.2%Moderate 12 · 4.9%High 1 · 0.4%

Infliximab vs adalimumab

Loss of clinical response (at 22 weeks, less than 100 points in CDAI change) · patients with Crohn's disease (active disease population with clinical response at baseline)

It is very uncertain whether infliximab changes loss of clinical response (at 56 weeks, less than 100 points in CDAI… compared with adalimumab (very low certainty).

1 finding from 1 review

Infliximab vs placebo

Withdrawals due to adverse events · patients with Crohn's disease (mixed disease activity population with clinical response at baseline)

It is very uncertain whether infliximab changes withdrawal due to adverse events (at 32‐54 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Infliximab combined with purine analogues vs purine analogues

Clinical relapse · Participants with Crohn's disease in remission

Infliximab combined with purine analogues probably leads to lower clinical relapse (at 48 weeks, CDAI of 150 or greater together with… compared with purine analogues (moderate certainty).

1 finding from 1 review

Infliximab combined with purine analogues vs purine analogues

Withdrawals due to adverse events · Participants with Crohn's disease in remission

It is very uncertain whether infliximab combined with purine analogues changes withdrawal due to adverse events (at 48 weeks) compared with purine analogues (very low certainty).

1 finding from 1 review

Infliximab combined with purine analogues vs purine analogues

Serious adverse events (at 48 weeks to 2 years) · Participants with Crohn's disease in remission

It is very uncertain whether infliximab combined with purine analogues changes serious adverse events (at 48 weeks to 2 years) compared with purine analogues (very low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Histological improvement (dichotomous) · inactive EoE patients

Corticosteroids probably leads to higher histological improvement (dichotomous) compared with placebo (moderate certainty).

1 finding from 1 review