Adverse events (minor bleeding) · people hospitalised with COVID‐19
Higher‐dose anticoagulants leads to higher adverse events (minor bleeding) compared with lower‐dose anticoagulants (high certainty).
1 finding from 1 review
Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support
HFNC may leads to lower treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with standard oxygen therapy (low certainty).
1 finding from 1 review
Adverse events ‐ pneumonia · adults in the ICU, requiring respiratory support
It is very uncertain whether HFNC changes adverse events Respiratory infection (pneumonia) compared with NIPPV or NIV (very low certainty).
1 finding from 1 review
Barotrauma (pneumothorax) · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in barotrauma (pneumothorax) compared with NIPPV or NIV (low certainty).
1 finding from 1 review
Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Duration of ICU stay · adults in the ICU, requiring respiratory support
1 finding from 1 review
Respiratory effects: PaO2/FiO2 ratio up to 24 hours after initiation of therapy · adults in the ICU, requiring respiratory support
1 finding from 1 review
In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).
1 finding from 1 review
Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).
1 finding from 1 review
Duration of ICU stay · adults in the ICU, requiring respiratory support
1 finding from 1 review
Respiratory effects: PaO2/FiO2 ratio up to 24 hours after initiation of therapy · adults in the ICU, requiring respiratory support
1 finding from 1 review
Treatment failure (escalation of respiratory therapy to NIV, NIPPV or invasive ventilation) Measured up to 28 days · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in treatment failure (escalation of respiratory therapy to NIV, NIPPV… compared with NIPPV or NIV (low certainty).
1 finding from 1 review
In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support
HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with NIPPV or NIV (low certainty).
1 finding from 1 review
Intervention not reported
Functional exercise capacity Multiple different outcome measures used SF‐36 PF and AT (at 9 and 26 weeks) (Batterham 2014) SF‐36 PF and 6MWT (at 8 and 26 weeks) (Elliott 2011) ABC, Katz, TUAG (at 3 months) (Jackson 2012) SF‐36 PCS ( · adult survivors of critical illness
1 finding from 1 review
Intervention not reported
Health‐related quality of life Multiple different outcome measures used EQ‐5D and EQ‐5D VAS (9 and 26 weeks) (Batterham 2014) SF‐36 PCS and MCS (8 and 26 weeks) (Elliott 2011) · adult survivors of critical illness
1 finding from 1 review
Intervention not reported
Adherence Participant completion of the intervention as described in the trial method · adult survivors of critical illness
1 finding from 1 review
Intervention not reported
Mortality Death at any point during the trial duration · adult survivors of critical illness
1 finding from 1 review
Intervention not reported
Loss to · adult survivors of critical illness
1 finding from 1 review
Intervention not reported
Other adverse events Non‐mortality · adult survivors of critical illness
1 finding from 1 review