Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

53 questions · 56 findings · 4 reviews · Headline outcomes only

No studies found 15 · 26.8%GRADE not reported 0 · 0%Very low 23 · 41.1%Low 10 · 17.9%Moderate 5 · 8.9%High 3 · 5.4%

N‐acetylcysteine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

N‐acetylcysteine showed no clear difference in efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (low certainty).

1 finding from 1 review