Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

218 questions · 245 findings · 8 reviews · Incontinence

No studies found 127 · 51.8%GRADE not reported 10 · 4.1%Very low 62 · 25.3%Low 33 · 13.5%Moderate 12 · 4.9%High 1 · 0.4%

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ amitriptyline vs placebo · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (very low certainty).

2 findings from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy (reassurance, retention control training + wakening, parental involvement) · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights at the end of treatment ‐ imipramine vs 3 step therapy + motivation/counselling + education · children with nocturnal enuresis

Tricyclics may leads to higher number not achieving 14 consecutive dry nights at the end of… compared with behavioural interventions (low certainty).

1 finding from 1 review

Tricyclic antidepressants vs behavioural interventions

Number not achieving 14 consecutive dry nights or relapsing at · children with nocturnal enuresis

It is very uncertain whether tricyclics changes number not achieving 14 consecutive dry nights or relapsing at compared with behavioural interventions (very low certainty).

2 findings from 1 review

Electrical or magnetic stimulation vs no treatment, sham treatment or verbal/written instruction

Number of participants experiencing surface or skin‐related adverse events: e.g. skin reactions, bruising, hypersensitivity to gel · men with urinary incontinence following prostate surgery

The review found no eligible studies for this question.

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Perception of improvement or cure · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in subjective cure or improvement: patient‐reported as defined by the… compared with no treatment, sham treatment or verbal/written instruction (low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Disease‐specific quality of life · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in condition‐specific quality of life: using validated questionnaires,… compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Objective cure or improvement: > 6 to 12 months · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in objective cure or improvement: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (high certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

Adherence · men with urinary incontinence following prostate surgery

It is very uncertain whether combinations of conservative treatments changes participant adherence to the intervention: as reported by the… compared with no treatment, sham treatment or verbal/written instruction (very low certainty).

1 finding from 1 review

Combinations of conservative treatments vs no treatment, sham treatment or verbal/written instruction

QoL · men with urinary incontinence following prostate surgery

Combinations of conservative treatments showed no clear difference in general quality of life: > 6 to 12 months compared with no treatment, sham treatment or verbal/written instruction (moderate certainty).

1 finding from 1 review