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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 45 findings · 11 reviews · Headline outcomes only

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No studies found 6 · 13.3%GRADE not reported 2 · 4.4%Very low 1 · 2.2%Low 11 · 24.4%Moderate 14 · 31.1%High 11 · 24.4%

Intervention not reported

Death at any time in trial period case mortality count · Patients with acute traumatic brain injury

The intervention probably leads to lower death at any time in trial period case mortality count (moderate certainty).

1 finding from 1 review

Intervention not reported

Favourable outcome GOS <9 or similar · Patients with acute traumatic brain injury

The intervention showed no clear difference in favourable outcome GOS <9 or similar; GRADE not reported.

1 finding from 1 review

Intervention not reported

Mean improvement in pure‐tone average hearing threshold across all frequencies Decibels Scale from: 0 to 120 · patients with idiopathic sudden sensorineural hearing loss or tinnitus
1 finding from 1 review

Intervention not reported

More than 50% improvement in pure‐tone average threshold Risk ratio · patients with idiopathic sudden sensorineural hearing loss or tinnitus

The intervention showed no clear difference in more than 50% improvement in pure‐tone average threshold Risk ratio (moderate certainty).

1 finding from 1 review

Intervention not reported

More than 25% improvement in pure‐tone average threshold Risk ratio · patients with idiopathic sudden sensorineural hearing loss or tinnitus

The intervention probably leads to higher more than 25% improvement in pure‐tone average threshold Risk ratio (moderate certainty).

1 finding from 1 review