What do systematic reviews say?

Fluoxetine vs amineptine

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with amineptine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.61 [0.17, 2.21]
  2 studies · 232 participants
  Moderate

Fluoxetine vs amineptine

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with amineptine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.04 [0.19, 5.57]
  1 study · 63 participants
  Moderate

Fluoxetine vs tricyclic antidepressants (TCAs)

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  50 studies · 3393 participants
  Moderate

Fluoxetine vs amineptine

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ (Copy) compared with amineptine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.52 [0.03, 7.82]
  2 studies · 232 participants
  Moderate

Fluoxetine vs AMISULPRIDE

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Fluoxetine vs AMISULPRIDE

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 268 participants
  Low

Fluoxetine vs AMISULPRIDE

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with amisulpride (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.39 [0.81, 2.38]
  1 study · 281 participants
  Low

Fluoxetine vs AMISULPRIDE

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with amisulpride (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.16 [0.43, 3.1]
  1 study · 281 participants
  Low

Fluoxetine vs AMISULPRIDE

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with amisulpride (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.77 [0.33, 1.82]
  1 study · 281 participants
  Low

Fluoxetine vs bupropion

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with bupropion (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.83 [0.48, 1.43]
  2 studies · 436 participants
  Moderate

Fluoxetine vs bupropion

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Fluoxetine vs bupropion

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with bupropion (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1 [0.67, 1.48]
  2 studies · 436 participants
  Moderate

Fluoxetine vs bupropion

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with bupropion (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.16 [0.33, 4.1]
  2 studies · 436 participants
  Moderate

Fluoxetine vs tricyclic antidepressants (TCAs)

Fluoxetine probably leads to lower failure to complete ‐ total ‐ compared with TCAs (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.79 [0.65, 0.96]
  49 studies · 4194 participants
  Moderate

Fluoxetine vs bupropion

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with bupropion (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.01 [0.45, 2.25]
  2 studies · 436 participants
  Moderate

Fluoxetine vs citalopram

It is very uncertain whether fluoxetine changes failure to respond (reduction ≥ 50% on HDRS) compared with citalopram (very low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.6 [0.2, 1.79]
  1 study · 59 participants
  Very low

Fluoxetine vs citalopram

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 661 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.87 [0.6, 1.27]
  3 studies · 732 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.87 [0.48, 1.56]
  3 studies · 732 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.64 [0.34, 1.2]
  3 studies · 732 participants
  Moderate