Findings

What do systematic reviews say?

199 questions · 200 findings · 7 reviews

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No studies found 13 · 6.5%GRADE not reported 16 · 8%Very low 26 · 13%Low 40 · 20%Moderate 100 · 50%High 5 · 2.5%

Fluoxetine vs amineptine

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs amineptine

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.61 [0.17, 2.21]
2 studies · 232 participants
Moderate

Fluoxetine vs amineptine

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.04 [0.19, 5.57]
1 study · 63 participants
Moderate

Fluoxetine vs tricyclic antidepressants (TCAs)

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
50 studies · 3393 participants
Moderate

Fluoxetine vs amineptine

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ (Copy) compared with amineptine (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.52 [0.03, 7.82]
2 studies · 232 participants
Moderate

Fluoxetine vs AMISULPRIDE

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs AMISULPRIDE

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
1 study · 268 participants
Low

Fluoxetine vs AMISULPRIDE

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with amisulpride (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.39 [0.81, 2.38]
1 study · 281 participants
Low

Fluoxetine vs AMISULPRIDE

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with amisulpride (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.16 [0.43, 3.1]
1 study · 281 participants
Low

Fluoxetine vs AMISULPRIDE

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with amisulpride (low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.77 [0.33, 1.82]
1 study · 281 participants
Low

Fluoxetine vs bupropion

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine showed no clear difference in failure to respond (reduction ≥ 50% on HDRS) compared with bupropion (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.83 [0.48, 1.43]
2 studies · 436 participants
Moderate

Fluoxetine vs bupropion

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Fluoxetine vs bupropion

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with bupropion (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1 [0.67, 1.48]
2 studies · 436 participants
Moderate

Fluoxetine vs bupropion

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with bupropion (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.16 [0.33, 4.1]
2 studies · 436 participants
Moderate

Fluoxetine vs tricyclic antidepressants (TCAs)

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine probably leads to lower failure to complete ‐ total ‐ compared with TCAs (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.79 [0.65, 0.96]
49 studies · 4194 participants
Moderate

Fluoxetine vs bupropion

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with bupropion (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.01 [0.45, 2.25]
2 studies · 436 participants
Moderate

Fluoxetine vs citalopram

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

It is very uncertain whether fluoxetine changes failure to respond (reduction ≥ 50% on HDRS) compared with citalopram (very low certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.6 [0.2, 1.79]
1 study · 59 participants
Very low

Fluoxetine vs citalopram

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 661 participants
Moderate

Fluoxetine vs citalopram

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with citalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.87 [0.6, 1.27]
3 studies · 732 participants
Moderate

Fluoxetine vs citalopram

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with citalopram (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 0.87 [0.48, 1.56]
3 studies · 732 participants
Moderate