Findings

What do systematic reviews say?

80 questions · 80 findings · 5 reviews

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No studies found 16 · 20%GRADE not reported 7 · 8.8%Very low 32 · 40%Low 15 · 18.8%Moderate 6 · 7.5%High 4 · 5%

Intervention not reported

False positivespeople incorrectly classified as having fluoroquinolone resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 640 participants
Moderate

Intervention not reported

Test result · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

The review found no eligible studies for this question.

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

True positivespeople with ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Very low

Intervention not reported

False negativespeople incorrectly classified as not having ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 167 participants
Very low

Intervention not reported

True negativespeople without ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 267 participants
Very low

Intervention not reported

True positivespeople with pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 799 participants
Very low

Intervention not reported

False positivespeople incorrectly classified as having ethionamide resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis positive by Xpert MTB/XDRRole: an initial…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 267 participants
Very low

Intervention not reported

Test result · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

The review found no eligible studies for this question.

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

True positivespeople with amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 65 participants
Low

Intervention not reported

False negativespeople incorrectly classified as not having amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 65 participants
Low

Intervention not reported

True negativespeople without amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 425 participants
High

Intervention not reported

False positivespeople incorrectly classified as having amikacin resistance · adults with pulmonary tuberculosis with known rifampicin resistance, detected as tuberculosis‐positive by Xpert MTB/XDR Index test: Xpert…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 425 participants
High

Intervention not reported

False negativespeople incorrectly classified as not having pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 799 participants
Very low

Intervention not reported

True negativespeople without pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 429 participants
Very low

Intervention not reported

False positivespeople incorrectly classified as having pulmonary tuberculosis · people with presumptive pulmonary tuberculosisRole: an initial testIndex test: Xpert MTB/XDRThreshold for index test: an automated result…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 429 participants
Very low

Intervention not reported

Test result · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

The review found no eligible studies for this question.

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

True positivespeople with isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 756 participants
Moderate

Intervention not reported

False negativespeople incorrectly classified as not having isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 756 participants
Moderate

Intervention not reported

True negativespeople without isoniazid resistance · adults with pulmonary tuberculosis irrespective of rifampicin resistance (i.e. whether or not their rifampicin resistance status was…

1 finding from 1 review

Xpert MTB/XDR for detection of pulmonary tuberculosis and resistance to isoniazid, fluoroquinolones, ethionamide, and… 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 327 participants
Moderate

Fluoroquinolone plus standard regimen vs standard regimen

Treatment failure · Patients with presumed drug‐sensitive TB

1 finding from 1 review

Fluoroquinolones for treating tuberculosis (presumed drug‐sensitive) 2013 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported