Proportion of children not remaining caries-free · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Tooth staining/discolouration (adverse effect) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
Show 4 more findings
PF 0.28 [0.19, 0.37]
22 studies
GRADE not reported
PF 0.40 [0.31, 0.49]
17 studies
GRADE not reported
PF 0.24 [0.21, 0.28]
70 studies
GRADE not reported
PF 0.46 [0.30, 0.63]
7 studies
GRADE not reported
Caries increment on primary (deciduous) tooth surfaces (d(e/m)fs), prevented fraction · Children with primary (deciduous) teeth (younger children)
5 findings from 1 review
PF 0.26 [-0.11, 0.63]
2 studies
GRADE not reported
PF 0.41 [0.26, 0.55]
2 studies
GRADE not reported
PF 0.27 [0.08, 0.48]
3 studies
GRADE not reported
Show 2 more findings
PF 0.33 [0.22, 0.44]
5 studies
GRADE not reported
PF 0.33 [0.19, 0.48]
3 studies
GRADE not reported
Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
PF 0.26 [0.21, 0.30]
79 studies
GRADE not reported
PF 0.53 [0.23, 0.82]
3 studies
GRADE not reported
PF 0.32 [0.19, 0.46]
10 studies
GRADE not reported
Show 4 more findings
PF 0.45 [0.32, 0.58]
7 studies
GRADE not reported
PF 0.24 [0.18, 0.30]
13 studies
GRADE not reported
PF 0.24 [0.20, 0.28]
72 studies
GRADE not reported
PF 0.23 [0.19, 0.28]
53 studies
GRADE not reported
Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported
Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 1.20 [0.85, 1.70]
10 studies
GRADE not reported
Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… led to lower proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 0.88 [0.82, 0.95]
13 studies
GRADE not reported
Caries increment in permanent teeth · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
The illustrative network meta-regression estimated an SMD for caries increment for fluoride in gel versus fluoride in rinse across randomization year; the review did not state whether the difference was significant and certainty was not graded.
1 finding from 1 review
Slow-release fluoride devices vs Alternative fluoride therapy (topical fluoride: toothpaste, mouthrinse, gel, or varnish)
Outcome not reported · Children or adults
The review found no eligible studies for this question.
1 finding from 1 review
Caries increment, surface index D(M)FS · Children or adolescents
The illustrative network meta-regression estimated an SMD for caries increment for fluoride in varnish versus fluoride in rinse across randomization year; the review did not state whether the difference was significant and certainty was not graded.
1 finding from 1 review
Fluorosis (adverse effect; % of children with fluorotic teeth) · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Caries increment in permanent teeth · Children and adolescents aged 16 years or less
2 findings from 1 review
Plaque and gingivitis scores · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in deciduous (primary) teeth/surfaces (dmf index) · Children and adolescents aged 16 years or less
1 finding from 1 review
Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
1 finding from 1 review
Additional SoF Table 3. Adverse effects: current design of the fluoride glass bead inadequate; high attrition partly due to bead breakages ('an improved method of attachment is needed'). 37 participants (1 RCT, Luther…
1 study · 37 participants
Very low
Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether intraoral fluoride-releasing glass bead device attached to the brace changes number of participants with new demineralised lesions (DLs) compared with 250 ppm F (daily) fluoride mouthrinse (very low certainty).
1 finding from 1 review