Findings

What do systematic reviews say?

165 questions · 165 findings · 18 reviews

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No studies found 65 · 39.4%GRADE not reported 6 · 3.6%Very low 25 · 15.2%Low 31 · 18.8%Moderate 33 · 20%High 5 · 3%

Phenobarbital vs diazepam

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs diazepam

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Low

Phenobarbital vs diazepam

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Low

Phenobarbital vs diazepam

Adverse events To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs diazepam

Treatment failure To discharge · newborn infants with opioid withdrawal

Phenobarbital may leads to lower treatment failure To discharge compared with diazepam (low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.39 [0.24, 0.62]
2 studies · 139 participants
Low

Phenobarbital vs diazepam

Seizures To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs diazepam

Treatment failure To discharge · newborn infants with opioid withdrawal

Opioid may leads to lower treatment failure To discharge compared with diazepam (low certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.43 [0.23, 0.8]
2 studies · 86 participants
Low

Opioids vs diazepam

Seizures To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs diazepam

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs diazepam

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs diazepam

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Opioids vs diazepam

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 33 participants
Very low

Opioids vs diazepam

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 6 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 12 months · children with febrile seizures

Continuous phenobarbital showed no clear difference in recurrent seizure at 12 months compared with intermittent rectal or oral diazepam (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.48 [0.75, 2.94]
1 study · 145 participants
Low

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 18 months · children with febrile seizures

It is very uncertain whether continuous phenobarbital changes recurrent seizure at 18 months compared with intermittent rectal or oral diazepam (very low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.25 [0.36, 4.38]
1 study · 100 participants
Very low

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 24 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 36 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 48 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs intermittent rectal or oral diazepam

Recurrent seizure at 60 months or greater · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found