What do systematic reviews say?

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

Summary of findings table (subcomparison 4): targeted therapy agent… probably leads to lower progression‐free survival compared with control intervention alone (moderate certainty).

• Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer 2017 · Cochrane Headline outcomes only
  HR 0.64 [0.45, 0.92]
  5 studies · 883 participants
  Moderate

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

It is very uncertain whether summary of findings table (subcomparison 4): targeted therapy agent… changes toxicity compared with control intervention alone (very low certainty).

• Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 3020 participants
  Very low

Summary of findings table (subcomparison 4): targeted therapy agent plus control intervention vs control intervention

• Palliative chemotherapy and targeted therapies for esophageal and gastroesophageal junction cancer 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 2054 participants
  Very low

Intervention not reported

The intervention probably leads to lower lymph node mets analysis ‐ N+ OS (moderate certainty).

• Post‐surgical chemotherapy versus surgery alone for resectable gastric cancer 2013 · Cochrane Headline outcomes only
  HR 0.78 [0.67, 0.91]
  4 studies · 877 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in stage OS analysis ‐ T1/2 OS (moderate certainty).

• Post‐surgical chemotherapy versus surgery alone for resectable gastric cancer 2013 · Cochrane Headline outcomes only
  HR 0.86 [0.71, 1.05]
  5 studies · 1146 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in stage OS analysis ‐ T3/4 OS (moderate certainty).

• Post‐surgical chemotherapy versus surgery alone for resectable gastric cancer 2013 · Cochrane Headline outcomes only
  HR 0.66 [0.41, 1.08]
  4 studies · 1008 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in lymph node mets analysis ‐ N‐ OS (moderate certainty).

• Post‐surgical chemotherapy versus surgery alone for resectable gastric cancer 2013 · Cochrane Headline outcomes only
  HR 0.74 [0.41, 1.33]
  2 studies · 402 participants
  Moderate