Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

49 questions · 50 findings · 8 reviews · Epilepsy

No studies found 6 · 12%GRADE not reported 0 · 0%Very low 3 · 6%Low 18 · 36%Moderate 15 · 30%High 8 · 16%

Clobazam vs carbamazepine

Seizure freedom · people with focal or generalized seizures

Clobazam showed no clear difference in seizure freedom at 4 weeks compared with carbamazepine (low certainty).

2 findings from 1 review

VGB vs CBZ monotherapy

Time to achieve 6‐month remission after the first 6 weeks of dose stabilisation from randomisation · people with epilepsy

It is very uncertain whether VGB changes time to achieve 6‐month remission after the first 6 weeks of dose… compared with CBZ monotherapy (very low certainty).

1 finding from 1 review

VGB vs CBZ monotherapy

Time to first seizure (post‐randomisation) All participants Range of · people with epilepsy

VGB may leads to higher time to first seizure after randomisation compared with CBZ monotherapy (low certainty).

1 finding from 1 review