Findings

What do systematic reviews say?

45 questions · 67 findings · 10 reviews

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No studies found 0 · 0%GRADE not reported 64 · 95.5%Very low 1 · 1.5%Low 1 · 1.5%Moderate 1 · 1.5%High 0 · 0%

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected Significant Caries (SiC) index · Alaska Native children (below age 18)

A simulation projected a 50% drop in the Significant Caries index for children (12.3 to 6.1) under the PDHA model (certainty not graded).

2 findings from 1 review

Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20-year projection · Alaska Native communities (simulation of the Alaska Dental Health Aide program) · Children overall
Significant Caries (SiC) index, children 6.1
1 study
GRADE not reported
Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20-year projection · Alaska Native communities (simulation of the Alaska Dental Health Aide program) · 12-year-olds
Significant Caries (SiC) index, 12-year-olds 3.3
1 study
GRADE not reported

Primary dental health aide (PDHA) service-delivery models (PDHA program; PDHA + intensive staffing; PDHA + robust prevention) vs Baseline pre-intervention service-delivery scenario

Projected proportion of caries-free children (5-18 years) · Alaska Native children (below age 18)

A simulation projected 0% of children aged 5-18 would be caries-free under the baseline scenario (certainty not graded).

3 findings from 1 review

Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20-year projection · Alaska Native communities (simulation of the Alaska Dental Health Aide program) · Baseline (pre-intervention) model
Caries-free children 5-18 y (%) 0
1 study
GRADE not reported
Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20-year projection · Alaska Native communities (simulation of the Alaska Dental Health Aide program) · PDHA + robust prevention model
Caries-free children 5-18 y (%) >50
1 study
GRADE not reported
Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20-year projection · Alaska Native communities (simulation of the Alaska Dental Health Aide program) · PDHA or PDHA + intensive staffing model
Caries-free children 5-18 y (%) 8
1 study
GRADE not reported

PDHA program vs Baseline pre-intervention service-delivery scenario

Significant caries index · Alaska children

The PDHA program was projected to reduce the SiC index 50% from 12.3 to 6.1 for children, without a GRADE rating.

1 finding from 1 review

Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20 years · Alaska · Children
Percent reduction in SiC index 50
1 study
GRADE not reported

PDHA program vs Baseline pre-intervention service-delivery scenario

Significant caries index · Alaska children aged 12 years

The PDHA program was projected to reduce the SiC index 70% from 10.5 to 3.3 for 12-year-olds, without a GRADE rating.

1 finding from 1 review

Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes
20 years · Alaska · Age 12 years
Percent reduction in SiC index 70
1 study
GRADE not reported

Stevia (high-intensity/non-nutritive sweetener) in a daily snack vs Baseline (within-group change); white sugar snack is a parallel arm with no between-group effect size reported

Change in Mutans streptococci (MS) and Lactobacilli in saliva · Schoolchildren (6-9 years), high caries risk

The single stevia trial (Cocco 2019) reported a significant reduction in salivary Mutans streptococci and lactobacilli, but gave no effect size and was not GRADE-rated.

1 finding from 1 review

Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. 2024 All outcomes
42 days · Schoolchildren in Italy, high caries risk; sweetener delivered as a daily snack · Single study (Cocco 2019); not pooled
Cocco 2019 (the only high-intensity sweetener trial): the stevia snack showed a significant decrease in MS (P < .01) and in lactobacilli (P = .03) versus baseline, whereas the white-sugar snack showed no significant…
1 study · 271 participants
GRADE not reported