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Evidence found and GRADE certainty

51 questions · 51 findings · 2 reviews · Skin

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No studies found 8 · 15.7%GRADE not reported 1 · 2%Very low 2 · 3.9%Low 30 · 58.8%Moderate 10 · 19.6%High 0 · 0%

Loratadine 10 mg vs emedastine 2 mg

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs hydroxyzine 25 mg

Complete suppression of urticaria: short‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

1 finding from 1 review

Hydroxyzine 25 mg vs placebo

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Hydroxyzine 25 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review

Desloratadine 5 to 20 mg vs placebo

Adverse effects requiring withdrawal/discontinuation of study medication · patients with chronic spontaneous urticaria

Desloratadine 5 to 20 mg showed no clear difference in adverse effects leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review