Findings

What do systematic reviews say?

113 questions · 113 findings · 6 reviews · Vascular

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No studies found 21 · 18.6%GRADE not reported 10 · 8.8%Very low 0 · 0%Low 32 · 28.3%Moderate 39 · 34.5%High 11 · 9.7%

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Recurrent VTE · participants with diagnosed DVT

Oral DTIs showed no clear difference in recurrent VTE (7 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.17 [0.83, 1.65]
3 studies · 5994 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

Non‐fatal PE (3 to 12 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in non‐fatal PE (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.93 [0.68, 1.27]
7 studies · 15166 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

All‐cause mortality (3 to 6 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in all‐cause mortality (3 to 6 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.87 [0.67, 1.14]
9 studies · 10770 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

Major bleeding · participants with diagnosed DVT

Oral factor Xa inhibitors leads to lower major bleeding (3 to 12 months) compared with conventional anticoagulation (high certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.63 [0.45, 0.89]
17 studies · 18066 participants
High

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Recurrent DVT (3 to 12 months) · participants with diagnosed DVT

Oral DTIs showed no clear difference in recurrent DVT (7 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.11 [0.74, 1.66]
3 studies · 5994 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Fatal PE (3 to 12 months) · participants with diagnosed DVT

Oral DTIs showed no clear difference in fatal PE (7 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.32 [0.29, 6.02]
3 studies · 5994 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Non‐fatal PE (3 to 12 months) · participants with diagnosed DVT

Oral DTIs showed no clear difference in non‐fatal PE (7 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.29 [0.64, 2.59]
3 studies · 5994 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

All‐cause mortality (7 months) · participants with diagnosed DVT

Oral DTIs showed no clear difference in all‐cause mortality (7 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.66 [0.41, 1.08]
1 study · 2489 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Major bleeding · participants with diagnosed DVT

Oral DTIs leads to lower major bleeding (7 months) compared with conventional anticoagulation (high certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.58 [0.38, 0.89]
3 studies · 5994 participants
High

Oral factor Xa inhibitors vs conventional anticoagulation

Recurrent VTE · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in recurrent VTE (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.85 [0.71, 1.01]
13 studies · 17505 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

Recurrent DVT (3 to 12 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in recurrent DVT (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.7 [0.49, 1.01]
9 studies · 16439 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

Fatal PE (3 to 12 months) · participants with diagnosed DVT

Oral factor Xa inhibitors showed no clear difference in fatal PE (3 to 12 months) compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.18 [0.69, 2.02]
6 studies · 15082 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Recurrent PE · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in recurrent PEa compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.02 [0.5, 2.04]
1 study · 1602 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

All‐cause mortality · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in all‐cause mortality compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 1.16 [0.79, 1.7]
1 study · 4817 participants
Moderate

Oral factor Xa inhibitors vs conventional anticoagulation

Major bleedinge · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral factor Xa inhibitors showed no clear difference in major bleedinge compared with conventional anticoagulation (low certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.71 [0.36, 1.41]
8 studies · 11447 participants
Low

Oral factor Xa inhibitors vs conventional anticoagulation

Health‐related quality of life · patients with a pulmonary embolism, confirmed by standard imaging techniques

The review found no eligible studies for this question.

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Recurrent VTEc · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in recurrent VTEc compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.93 [0.52, 1.66]
1 study · 1602 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

DVTd · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in DVTd compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.79 [0.29, 2.13]
1 study · 1602 participants
Moderate

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

All‐cause mortality · patients with a pulmonary embolism, confirmed by standard imaging techniques

The review found no eligible studies for this question.

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral direct thrombin inhibitors (DTIs) vs conventional anticoagulation

Major bleedinge · patients with a pulmonary embolism, confirmed by standard imaging techniques

Oral direct thrombin inhibitors (DTIs) showed no clear difference in major bleedinge compared with conventional anticoagulation (moderate certainty).

1 finding from 1 review

Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of… 2023 · Cochrane Headline outcomes only
OR 0.5 [0.15, 1.68]
1 study · 1527 participants
Moderate